Polyamines are ubiquitous and essential components of mammalian cells. They have
multiple functions including critical roles in nucleic acid and protein synthesis, gene …

Polyamines are ubiquitous small basic molecules that play multiple essential roles in
mammalian physiology. Their cellular content is highly regulated and there is convincing …

Since their discovery by Antoni van Leeuwenhoek in 1678 until the recent development of
transgenic mice expressing proteins altering polyamine levels in a tissue-specific manner …

This chapter provides an overview of the polyamine field and introduces the 32 other
chapters that make up this volume. These chapters provide a wide range of methods …

The aliphatic polyamines, putrescine, spermidine and spermine, are normal cell constituents
that play important roles in cell proliferation and differentiation. The equilibrium between …

Biosynthesis of the polyamines spermidine and spermine and their precursor putrescine is
controlled by the activity of the two key enzymes ornithine decarboxylase (ODC) and S …

The polyamines, spermidine and spermine, were first discovered in 1678 by Antonie van
Leeuwenhoek. In the early part of the 20th century their structure was determined (Figure 1) …

Putrescine, spermine, and spermidine are the important polyamines (PAs), found in all living
organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell …

Several amine oxidases are involved in the metabolism of the natural polyamines
putrescine, spermidine, and spermine, and play a role in the regulation of intracellular …

PerspectivesinBiologyandMedicine· Spring1979\421 metabolism of polyamines have been
uncovered in animals, plants, and microorganisms. Various polyamine biosynthetic …