Receptor Tyrosine Kinases class I (RTK class I, EGF receptor family) constitute a family of
transmembrane proteins involved in various aspects of cell growth and survival and have …

Growth factor receptors and their ligands not only regulate normal cell processes but have
been also identified as key regulators of human cancer formation. The epidermal growth …

Receptor tyrosine kinases (RTKs) are a superfamily of transmembrane proteins that mediate
intracellular signaling by phosphorylating substrate proteins involved in cell proliferation …

The EGFR family is among the most investigated receptor protein-tyrosine kinase groups
owing to its general role in signal transduction and in oncogenesis. This family consists of …

Conventional anticancer therapy using cytotoxic drugs lacks selectivity and is prone to
toxicity and drug resistance. Anticancer therapies targeting aberrant growth factor receptor …

THE EPIDERMAL GROWTH factor receptor (EGFR) is composed of an extra cellular ligand-
binding domain, a transmembrane lipophilic segment, and an intracellular protein kinase …

Lung cancer is the leading cause of death worldwide. Current treatment modalities,
including chemotherapy, radiotherapy and surgery, provide only limited improvement in the …

In the search for rational targets for drug development in cancer, receptor tyrosine kinases
have become a favorite. The rationale for directing efforts to developing inhibitors of these …

The varying efficacy and toxicity of traditional cancer therapies has driven the development
of novel target-based agents. Members of the HER (Human Epidermal Receptor) family, in …

Tyrosine kinases are known to play a role in tumour growth and proliferation, and they have
become common drug targets. Tyrosine kinase inhibitors (TKIs) prohibit associated kinases …