Objective Carbon monoxide (CO) may counteract obesity and metabolic dysfunction in
rodents consuming high‐fat diets, but the skeletal effects are not understood. This study …

Bone microarchitecture and strength are impaired by obesity and physical inactivity, but the
underlying molecular regulation of bone metabolism in response to these factors is not well …

Marrow adipose tissue (MAT) and its relevance to skeletal health during caloric restriction
(CR) is unknown: It remains unclear whether exercise, which is anabolic to bone in a calorie …

This study investigated whether exercise or antioxidant supplementation with vitamin C and
E during exercise affects bone structure and markers of bone metabolism in obese rat …

Background Previous studies have demonstrated that induction of heme oxygenase-1
results in weight loss in several rodent models of obesity. However, the specific role of the …

The association of a well-balanced diet with exercise is a key strategy to treat obesity.
However, weight loss is linked to an accelerated bone loss. Furthermore, exercise is known …

Dietary energy deficits leading to weight loss can induce loss of bone. We sought to
elucidate whether endurance exercise can mitigate bone loss in virgin female rats subjected …

Although caloric restriction (CR) could delay biologic aging in humans, it is unclear if this
would occur at the cost of significant bone loss. We evaluated the effect of prolonged CR on …

Caloric restriction (CR) is now a popular lifestyle choice due to its ability in experimental
animals to improve lifespan, reduce body weight, and lessen oxidative stress. However …

Weight reduction through caloric restriction (CR) or exercise can have opposite effects on
bone. This study investigated the effects of comparable weight reduction through CR and/or …