Aging is a major risk factor of high incidence and increased mortality of acute respiratory
distress syndrome (ARDS). Here, we demonstrated that persistent lung injury and high …

Recovery of endothelial integrity after vascular injury is vital for endothelial barrier function
and vascular homeostasis. However, little is known about the molecular mechanisms of …

Rationale: Angioproliferative vasculopathy is a hallmark of pulmonary arterial hypertension
(PAH). However, little is known about how endothelial cell (EC) and smooth muscle cell …

Multiple signaling pathways, structural proteins, and transcription factors are involved in the
regulation of endothelial barrier function. The forkhead protein FOXF1 is a key …

FOXO3 is an evolutionarily conserved transcription factor that has been linked to longevity.
Here we wanted to find out whether human vascular cells could be functionally enhanced by …

Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types.
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …

Pulmonary arterial hypertension (PAH) is a progressive vascular remodeling disease
characterized by a persistent elevation of pulmonary artery pressure, leading to right heart …

Rationale: Endothelial dysfunction results in sustained and chronic vascular inflammation,
which is central to atherosclerotic diseases. However, transcriptional regulation of vascular …

The alveolar epithelium is composed of the flat type I cells comprising 95% of the gas-
exchange surface area and cuboidal type II cells comprising the rest. Type II cells are …

Rationale: Inflammation in post–myocardial infarction (MI) is necessary for myocyte repair
and wound healing. Unfortunately, it is also a key component of subsequent heart failure …