Oxysterols are cholesterol metabolites generated in the liver and other peripheral tissues as
a mechanism of removing excess cholesterol. Oxysterols have a wide range of biological …

Cholesterol has been implicated in the pathophysiology and progression of several cancers
now, although the mechanisms by which it influences cancer biology are just emerging. Two …

Several studies have suggested an etiological role for hypercholesterolemia in the
pathogenesis of breast cancer and prostate cancer (PCa). However, the molecular …

Cholesterol is an essential lipid that serves several important functions, including
maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid …

Background The hydroxylated derivatives of cholesterol, such as the oxysterols, play
important roles in lipid metabolism. In particular, 25-hydroxycholesterol (25HC) has been …

As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the
precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind …

Direct translation of findings achieved in experimental cell or animal models to humans is
quite a difficult task. We focused here only on the epidemiological and ex vivo human …

27-hydroxycholesterol (27HC) is an abundant cholesterol metabolite in human circulation
and promotes breast cancer cell proliferation. Although lung is one of the organs that contain …

Colorectal cancer (CRC) is the third most diagnosed cancer in the western world, affecting 1
out of approximately 22 people in their lifetime. Several epidemiological studies suggest a …

Glioblastoma is the most frequent primary malignant brain tumor in adults. Oxysterols are
oxidation products of cholesterol generated by enzymatic reactions. 27‑hydroxycholesterol …