Progenitor-like CD8+ T cells mediate long-term immunity to chronic infection and cancer and
respond potently to immune checkpoint blockade. These cells share transcriptional …

After infection, many factors coordinate the population expansion and differentiation of CD8+
effector and memory T cells. Using data of unparalleled breadth from the Immunological …

Naïve CD4+ T cells coordinate the immune response by acquiring an effector phenotype in
response to cytokines. However, the cytokine responses in memory T cells remain largely …

Abstract Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector
function, high co-expression of inhibitory receptors and extensive transcriptional changes …

Cytotoxic T cells are essential mediators of protective immunity to viral infection and
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …

Central memory CD8+ T cells (Tcm) control systemic secondary infections and can protect
from chronic infection and cancer as a result of their stem-cell-like capacity to expand …

Tick-TOX, it’s time for T cell exhaustion | Nature Immunology Skip to main content Thank you
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CD8+ T cell exhaustion is a hallmark of many cancers and chronic infections. In mice, T cell
factor 1 (TCF-1) maintains exhausted CD8+ T cell responses, whereas thymocyte selection …

Clonal expansion is a core aspect of T cell immunity. However, little is known with respect to
the relationship between replicative history and the formation of distinct CD8+ memory T cell …

The mechanisms underlying the heightened protection mediated by central memory CD8+ T
(TCM) cells remain unclear. Here we show that the transcription factor Tcf1 was required in …