In the spinal cord, neuron and glial cells actively interact and contribute to neurofunction.
Surprisingly, both cell types have similar receptors, transporters and ion channels and also …

The hyperactive state of sensory neurons in the spinal cord enhances pain transmission.
Spinal glial cells have also been implicated in enhanced excitability of spinal dorsal horn …

Research focused on improving recovery of function, including the reduction of central
neuropathic pain (CNP) after spinal cord injury (SCI) is essential. After SCI, regional …

Spinal cord injury (SCI) impairs sensory systems causing chronic allodynia. Mechanisms
underlying neuropathic pain have been more extensively studied following peripheral nerve …

Neuropathic pain after spinal cord injury (SCI) is common, often intractable, and can be
severely debilitating. A number of mechanisms have been proposed for this pain, which are …

Chronic pain, a pathological state, affects millions of people worldwide. Despite decades of
study on the neuronal processing of pain, mechanisms underlying the creation and …

At the level of the spinal cord, pathological pain is classically viewed as being created and
maintained solely by neurons. Glia (microglia and astrocytes) were not considered to play a …

In this study, we evaluated whether astrocytic and microglial activation mediates below-level
neuropathic pain following spinal cord injury. Male Sprague–Dawley (225–250 g) rats were …

Contemporary studies illustrate that peripheral injuries activate glial components of the
peripheral and central cellular circuitry. The subsequent release of glial stressors or …

During neuropathic pain, glial cells (mainly astrocytes and microglia) become activated and
initiate a series of signaling cascades that modulate pain processing at both spinal and …