Background Microglia provide continuous immune surveillance of the CNS and upon
activation rapidly change phenotype to express receptors that respond to chemoattractants …

During neuroinflammation, activated microglial cells migrate toward dying neurons, where
they exacerbate local cell damage. The signaling molecules that trigger microglial cell …

GPR3 and GPR6 are members of a family of constitutively active, Gs protein-coupled
receptors. Previously, it has been reported that GPR3 is involved in Alzheimer's disease …

Microglial cells, the macrophages of the brain, express low, yet detectable levels of
cannabinoid CB1 receptors, which are known to modulate cell migration. To determine if …

The G protein-coupled receptors 3, 6, and 12 (GPR3, GPR6, and GPR12) comprise a family
of closely related orphan receptors with no confirmed endogenous ligands. These receptors …

Searching for chemical agents and molecular targets protecting against secondary neuronal
damage reflects one major issue in neuroscience. Cannabinoids limit neurodegeneration by …

The type‐1‐cannabinoid (CB1) receptor is amongst the most widely expressed G protein‐
coupled receptors in the brain. In few decades, CB1 receptors have been shown to regulate …

Recent years have yielded significant advances in our understanding of microglia, the
immune cells of the central nervous system (CNS). Microglia are key players in CNS …

The role of cannabinoid receptors in inflammation has been the topic of many research
endeavors. Despite this effort, to date the involvement of the endocannabinoid system (ECS) …

The GPR55 receptor is expressed abundantly in the brain, especially in the striatum,
suggesting it might fulfill a role in motor function. Indeed, motor behavior is impaired in mice …