Antiparkinsonian agents in investigational polymeric micro-and Nano-Systems

N Paccione, M Rahmani, E Barcia, S Negro - Pharmaceutics, 2022 - mdpi.com
Parkinson's disease (PD) is a devastating neurodegenerative disease characterized by
progressive destruction of dopaminergic tissue in the central nervous system (CNS). To …

Polymeric nanoparticles for dopamine and levodopa replacement in Parkinson's disease

OAA Alabrahim, HMES Azzazy - Nanoscale advances, 2022 - pubs.rsc.org
As the world's population ages, the incidence of Parkinson's disease (PD), the second most
common neurological ailment, keeps increasing. It is estimated that 1% of the global …

Micro-and nanotechnology approaches to improve Parkinson's disease therapy

PV Torres-Ortega, L Saludas, AS Hanafy… - Journal of controlled …, 2019 - Elsevier
Current therapies for Parkinson's disease are symptomatic and unable to regenerate the
brain tissue. In recent years, the therapeutic potential of a wide variety of neuroprotective …

Importance of nanoparticles for the delivery of antiparkinsonian drugs

S Silva, AJ Almeida, N Vale - Pharmaceutics, 2021 - mdpi.com
Parkinson's disease (PD) affects around ten million people worldwide and is considered the
second most prevalent neurodegenerative disease after Alzheimer's disease. In addition …

Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders

B Newland, H Newland, C Werner, A Rosser… - Progress in Polymer …, 2015 - Elsevier
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons
and represents a growing health burden to western societies. Like many neurodegenerative …

Nanomedicine to overcome current Parkinson's treatment liabilities: A systematic review

GH Hawthorne, MP Bernuci, M Bortolanza… - Neurotoxicity …, 2016 - Springer
Nanoparticles might be produced and manipulated to present a large spectrum of
properties. The physicochemical features of the engineered nanomaterials confer to them …

Parkinson's disease: Current drug therapy and unraveling the prospects of nanoparticles

A Paul, KS Yadav - Journal of Drug Delivery Science and Technology, 2020 - Elsevier
Abstract Parkinson's disease (PD), although being the second most prevalent
neurodegenerative disease (ND) encounters lack of definitive treatment and challenges in …

Drug development in Parkinson's disease: from emerging molecules to innovative drug delivery systems

E Garbayo, E Ansorena, MJ Blanco-Prieto - Maturitas, 2013 - Elsevier
Current treatments for Parkinson's disease (PD) are aimed at addressing motor symptoms
but there is no therapy focused on modifying the course of the disease. Successful treatment …

A neoteric annotation on the advances in combination therapy for Parkinson's disease: nanocarrier-based combination approach and future anticipation. Part II …

D Unnithan, A Sartaj, MK Iqubal, J Ali… - Expert opinion on drug …, 2024 - Taylor & Francis
Introduction The current treatment modalities available for Parkinson's disease (PD) prove
inadequate due to the inherent constraints in effectively transporting bioactive compounds …

Boosting drug discovery for Parkinson's: enhancement of the delivery of a monoamine oxidase-B inhibitor by brain-targeted PEGylated polycaprolactone-based …

M Pinto, C Fernandes, E Martins, R Silva, S Benfeito… - Pharmaceutics, 2019 - mdpi.com
The current pharmacological treatments for Parkinson's disease only offer symptomatic relief
to the patients and are based on the administration of levodopa and catechol-O …