[PDF][PDF] Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency
K Takeda, K Toda, T Saibara, M Nakagawa… - Journal of …, 2003 - Citeseer
Aromatase (CYP19) is a cytochrome P450 enzyme that catalyzes the formation of aromatic
C18 estrogens from C19 androgens. It is expressed in various tissues and contributes to sex …
C18 estrogens from C19 androgens. It is expressed in various tissues and contributes to sex …
Tissue-specific induction of 17 beta-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated …
LQ Fan, RC Cattley, JC Corton - Journal of Endocrinology, 1998 - joe.bioscientifica.com
Aromatase (CYP19) is a cytochrome P450 enzyme that catalyzes the formation of aromatic
C18 estrogens from C19 androgens. It is expressed in various tissues and contributes to sex …
C18 estrogens from C19 androgens. It is expressed in various tissues and contributes to sex …
Aromatase-deficient (ArKO) mice accumulate excess adipose tissue
MEE Jones, AW Thorburn, KL Britt, KN Hewitt… - The Journal of steroid …, 2001 - Elsevier
Aromatase is the enzyme which catalyses the conversion of C19 steroids into C18
estrogens. We have generated a mouse model wherein the Cyp19 gene, which encodes …
estrogens. We have generated a mouse model wherein the Cyp19 gene, which encodes …
Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity
MEE Jones, AW Thorburn, KL Britt… - Proceedings of the …, 2000 - National Acad Sciences
The aromatase-knockout (ArKO) mouse provides a useful model to examine the role that
estrogens play in development and homeostasis in mammals. Lacking a functional Cyp19 …
estrogens play in development and homeostasis in mammals. Lacking a functional Cyp19 …
The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis
KN Hewitt, WC Boon, Y Murata, MEE Jones… - …, 2003 - academic.oup.com
The aromatase knockout (ArKO) mouse cannot synthesize endogenous estrogens due to
disruption of the Cyp19 gene. We have shown previously, that ArKO mice present with age …
disruption of the Cyp19 gene. We have shown previously, that ArKO mice present with age …
Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse
KN Hewitt, K Pratis, MEE Jones, ER Simpson - Endocrinology, 2004 - academic.oup.com
The aromatase knockout (ArKO) mouse cannot synthesize endogenous estrogens due to a
disruption to the Cyp19 gene. Previously we have shown both male and female ArKO mice …
disruption to the Cyp19 gene. Previously we have shown both male and female ArKO mice …
Effect of estrogen deficiency in the male: the ArKO mouse model
Y Murata, KM Robertson, MEE Jones… - Molecular and cellular …, 2002 - Elsevier
Aromatase, the enzyme responsible for the conversion of androgens to estrogens, is present
in the mouse gonads, brain, adipose tissue and bone. Depletion of endogenous estrogens …
in the mouse gonads, brain, adipose tissue and bone. Depletion of endogenous estrogens …
Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse
ML Misso, Y Murata, WC Boon, MEE Jones… - …, 2003 - academic.oup.com
Estrogen deficiency in the aromatase knockout (ArKO) mouse leads to the development of
obesity by as early as 3 months of age, which is characterized by a marked increase in the …
obesity by as early as 3 months of age, which is characterized by a marked increase in the …
Models of aromatase insufficiency
ER Simpson - Seminars in reproductive medicine, 2004 - thieme-connect.com
The recent studies on humans with a defective gene that encodes aromatase P450
(P450arom) and aromatase knockout (ArKO) mice with a disrupted P450arom gene …
(P450arom) and aromatase knockout (ArKO) mice with a disrupted P450arom gene …
[PDF][PDF] Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17beta-oestradiol
K Toda, K Takeda, T Okada, S Akira… - Journal of …, 2001 - academia.edu
Abstract Aromatase P450 (CYP19) is an enzyme catalysing the conversion of androgens
into oestrogens. We generated mice lacking aromatase activity (ArKO) by targeted disruption …
into oestrogens. We generated mice lacking aromatase activity (ArKO) by targeted disruption …