[HTML][HTML] Current landscape of NRF2 biomarkers in clinical trials
Y Yagishita, TN Gatbonton-Schwager, ML McCallum… - Antioxidants, 2020 - mdpi.com
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …
[HTML][HTML] Keap1/Nrf2 signaling pathway
GP Sykiotis - Antioxidants, 2021 - mdpi.com
Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-
like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous …
like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous …
[HTML][HTML] NRF2 as an emerging therapeutic target
IM Copple, AT Dinkova-Kostova… - … medicine and cellular …, 2017 - ncbi.nlm.nih.gov
The transcription factor nuclear factor erythroid 2 related factor 2 (NRF2) is the master
regulator of the basal and inducible expression of a large network of cytoprotective genes …
regulator of the basal and inducible expression of a large network of cytoprotective genes …
[HTML][HTML] Advances and challenges in therapeutic targeting of NRF2
AT Dinkova-Kostova, IM Copple - Trends in pharmacological sciences, 2023 - cell.com
Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …
The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders
B Gao, A Doan, BM Hybertson - Clinical pharmacology: advances …, 2014 - Taylor & Francis
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2; encoded in humans by the NFE2L2 gene) is
a transcription factor that regulates the gene expression of a wide variety of cytoprotective …
a transcription factor that regulates the gene expression of a wide variety of cytoprotective …
Nrf2 in health and disease: current and future clinical implications
O Al-Sawaf, T Clarner, A Fragoulis, YW Kan… - Clinical …, 2015 - portlandpress.com
The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a major regulator
of oxidative stress defence in the human body. As Nrf2 regulates the expression of a large …
of oxidative stress defence in the human body. As Nrf2 regulates the expression of a large …
NRF2-targeted therapeutics: New targets and modes of NRF2 regulation
Pharmacological activation of the transcription factor nuclear factor-erythroid derived 2-like 2
(NRF2), the key regulator of the cellular antioxidant response, has been recognized as a …
(NRF2), the key regulator of the cellular antioxidant response, has been recognized as a …
Modulation of NRF2: biological dualism in cancer, targets and possible therapeutic applications
M Gallorini, S Carradori, E Panieri, M Sova… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …
Activators and inhibitors of NRF2: a review of their potential for clinical development
N Robledinos-Antón… - Oxidative medicine …, 2019 - Wiley Online Library
The transcription factor NRF2 (nuclear factor erythroid 2‐related factor 2) triggers the first
line of homeostatic responses against a plethora of environmental or endogenous …
line of homeostatic responses against a plethora of environmental or endogenous …
Transcriptional regulation by Nrf2
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …