Obesity induces ovarian inflammation and reduces oocyte quality

AP Snider, JR Wood - Reproduction, 2019 - rep.bioscientifica.com
In the United States, 36.5% of women between the ages of 20 and 39 years are obese. This
obesity results in not only metabolic disorders including type II diabetes and cardiovascular …

Inflammatory pathways linking obesity and ovarian dysfunction

RL Robker, LLY Wu, X Yang - Journal of reproductive immunology, 2011 - Elsevier
This review summarizes some of the recent advances in obesity research and describes
how we and others have built upon these findings to better understand the impact of obesity …

Inflammation and human ovarian follicular dynamics

CE Boots, ES Jungheim - Seminars in reproductive medicine, 2015 - thieme-connect.com
Inflammation is a biologic process that mediates tissue effects including vasodilation,
hyperemia, edema, collagenolysis, and cell proliferation through complex immunologic …

Obesity modulates inflammation and lipid metabolism oocyte gene expression: a single-cell transcriptome perspective

ML Ruebel, M Cotter, CR Sims… - The Journal of …, 2017 - academic.oup.com
Context: It is hypothesized that obesity adversely affects the ovarian environment, which can
disrupt oocyte maturation and embryonic development. Objective: This study aimed to …

Pathophysiological roles of chronic low‐grade inflammation mediators in polycystic ovary syndrome

M Rostamtabar, S Esmaeilzadeh… - Journal of cellular …, 2021 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common hormonal imbalance disease in
reproductive‐aged women. Its basic characteristics are ovulatory dysfunction and ovarian …

Role of hormonal and inflammatory alterations in obesity-related reproductive dysfunction at the level of the hypothalamic-pituitary-ovarian axis

M Goldsammler, Z Merhi, E Buyuk - Reproductive Biology and …, 2018 - Springer
Background Besides being a risk factor for multiple metabolic disorders, obesity could affect
female reproduction. While increased adiposity is associated with hormonal changes that …

Female reproductive dysfunctions and the gut microbiota

SB Chadchan, V Singh… - Journal of molecular …, 2022 - jme.bioscientifica.com
The gut microbiome is considered an endocrine organ that can influence distant organs and
associated biological pathways. Recent advances suggest that gut microbial homeostasis is …

Development of mammalian ovary

P Smith, D Wilhelm, RJ Rodgers - Journal of Endocrinology, 2014 - joe.bioscientifica.com
Obesity is an ongoing pandemic and serves as a causal factor of a wide spectrum of
metabolic diseases including diabetes, fatty liver disease, and cardiovascular disease. Much …

Inflammation in polycystic ovary syndrome: underpinning of insulin resistance and ovarian dysfunction

F González - Steroids, 2012 - Elsevier
Chronic low-grade inflammation has emerged as a key contributor to the pathogenesis of
Polycystic Ovary Syndrome (PCOS). A dietary trigger such as glucose is capable of inciting …

Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

F He, Y Li - Journal of ovarian research, 2020 - Springer
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder.
Typically, it is characterized by hirsutism, hyperandrogenism, ovulatory dysfunction …