While the distant organ environment is known to support metastasis of primary tumors, its
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …

Bone marrow mesenchymal stem cells (BMSCs) are multipotent stromal cells that can
differentiate into a variety of cell types. BMSCs are chemotactically guided towards the …

Oncogene-induced metabolic reprogramming is a hallmark of pancreatic cancer (PDAC), yet
the metabolic drivers of metastasis are unclear. In PDAC, obesity and excess fatty acids …

Tumor‐associated macrophages (TAM s) promote tumor growth and metastasis by
suppressing tumor immune surveillance. Herein, we provide evidence that the …

In breast cancer, a key feature of peritumoral adipocytes is their loss of lipid content
observed both in vitro and in human tumors. The free fatty acids (FFAs), released by …

Myeloid-derived suppressor cells (MDSC) promote tumor growth by blocking anti-tumor T
cell responses. Recent reports show that MDSC increase fatty acid uptake and fatty acid …

Neutrophils, the most abundant innate immune cells, function as crucial regulators of the
adaptive immune system in diverse pathological conditions, including metastatic cancer …

Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …

Increased lipogenesis is a hallmark of a wide variety of cancers and is under intense
investigation as potential antineoplastic target. Although brisk lipogenesis is observed in the …

Metastasis is the most malignant stage of cancer. Lipid metabolic abnormalities are now
increasingly recognized as characteristics of cancer cells. The accumulation of certain lipid …