Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …

Fluid shear stress is one of the most important mechanical forces acting upon vascular
endothelium, because of its location at the interface between the bloodstream and vascular …

Vascular endothelial cells (ECs) play significant roles in regulating circulatory functions.
Mechanical stimuli, including the stretch and shear stress resulting from circulatory pressure …

Endothelium lining the cardiovascular system is highly sensitive to hemodynamic shear
stresses that act at the vessel luminal surface in the direction of blood flow. Physiological …

The cardiovascular system is constantly exposed to mechanical forces, which play a pivotal
role in determining its structure and function [1, 2]. In the blood vessel, anatomical …

Arteries possess a remarkable ability to adjust their diameter to normalize the hemodynamic
characteristics of the blood flowing through them. The responses are both acute and, when …

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prohibited. production of prostacyclin and nitric oxide, increased secretion of chemokines …

As the inner lining of the vessel wall, vascular endothelial cells are poised to act as a signal
transduction interface between haemodynamic forces and the underlying vascular smooth …

Endothelial cells lining the circulation are continuously subjected to hemodynamic forces.
Because flow is known to influence constriction and relaxation of small arteries and is …

Endothelial cells (ECs) lining blood vessel walls respond to shear stress, a fluid mechanical
force generated by flowing blood, and the EC responses play an important role in the …