[HTML][HTML] CYP51 Mutations in the Fusarium solani Species Complex: First Clue to Understand the Low Susceptibility to Azoles of the Genus Fusarium

P Vermeulen, A Gruez, AL Babin, JP Frippiat… - Journal of Fungi, 2022 - mdpi.com
Members of Fusarium solani species complex (FSSC) are cosmopolitan filamentous fungi
responsible for invasive fungal infections in immunocompromised patients. Despite the …

Overinduction of CYP51A Gene After Exposure to Azole Antifungals Provides a First Clue to Resistance Mechanism in Fusarium solani Species Complex

M d'Agostino, T Lemmet, C Dufay, A Luc… - Microbial Drug …, 2018 - liebertpub.com
The genus Fusarium is largely represented in fungal infections, not only mostly in plants but
also in humans. Fungi belonging to the Fusarium solani species complex (FSSC) are those …

[HTML][HTML] Azole Resistance and cyp51A Mutation of Aspergillus fumigatus in a Tertiary Referral Hospital in Taiwan

TH Hsu, PY Huang, YC Fan, PL Sun - Journal of Fungi, 2022 - mdpi.com
Azole resistance in Aspergillus fumigatus has increasingly been reported worldwide. Its
major mechanism of resistance is mediated by mutations in cyp51A. The objective of this …

[HTML][HTML] Exploring the Potential Mechanism of Prothioconazole Resistance in Fusarium graminearum in China

F Zhou, A Han, Y Jiao, Y Cao, L Wang, H Hu, R Liu… - Journal of Fungi, 2023 - mdpi.com
The Fusarium head blight (FHB) caused by Fusarium graminearum is one of the most
important diseases threatening wheat production in China. However, the triazole sterol 14α …

[HTML][HTML] Contribution of NADPH-cytochrome P450 Reductase to Azole Resistance in Fusarium oxysporum

D He, Z Feng, S Gao, Y Wei, S Han… - Frontiers in Microbiology, 2021 - frontiersin.org
Fusarium species exhibit significant intrinsic resistance to most antifungal agents and
fungicides, resulting in high mortality rates among immunocompromised patients …

Aspergillus fumigatus clinical isolates carrying CYP51A with TR34/L98H/S297T/F495I substitutions detected after four-year retrospective azole resistance screening in …

L Pontes, CAG Beraquet, T Arai, GL Pigolli… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Azole antifungal resistance in Aspergillus fumigatus is a worldwide concern. As in most
public hospitals in Brazil, antifungal susceptibility tests are not routinely performed for …

Screening and Characterization of a Non-cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance

X Wei, P Chen, R Gao, Y Li, A Zhang… - Antimicrobial agents …, 2017 - Am Soc Microbiol
The rapid and global emergence of azole resistance in the human pathogen Aspergillus
fumigatus has drawn attention. Thus, a thorough understanding of its mechanisms of drug …

[HTML][HTML] A 23 bp cyp51A Promoter Deletion Associated With Voriconazole Resistance in Clinical and Environmental Isolates of Neocosmospora keratoplastica

JE James, E Lamping, J Santhanam, TJ Milne… - Frontiers in …, 2020 - frontiersin.org
In the fungal pathogen Aspergillus fumigatus, resistance to azole antifungals is often linked
to mutations in CYP51A, a gene that encodes the azole antifungal drug target lanosterol 14α …

Azole resistance in Aspergillus fumigatus: mechanisms, route of resistance selection, and clinical implications

S Seyedmousavi, P Verweij - 2017 - repub.eur.nl
The medical triazoles, itraconazole, voriconazole, and posaconazole, are the most widely
used drugs for the management of infections caused by the saprophytic mold Aspergillus …

Genomic perspective of triazole resistance in clinical and environmental Aspergillus fumigatus isolates without cyp51A mutations

C Sharma, S Nelson-Sathi, A Singh, MR Pillai… - Fungal genetics and …, 2019 - Elsevier
Aspergillus fumigatus is the most common etiologic agent of primarily all clinical
manifestations of aspergillosis. A steady increase in the number of azole resistant A …