Our previous work suggested that high SIRT1 expression by cancer cells predicted a poor
colorectal cancer (CRC) prognosis, but its role in the tumor microenvironment was unclear …

SIRT1, a NAD+ dependent class III deacetylase, takes part in many important biological
processes. Previous studies show that SIRT1 is overexpressed in some cancers and plays …

Over the past several years, SIRT5 has attracted considerable attention in metabolic
regulation. However, the function of SIRT5 in tumorigenesis by regulating tumor …

Background The activation of tumour-associated macrophages (TAMs) contributes to the
progression of hepatocellular carcinoma (HCC). SIRT4 acts as a tumour suppressor of …

Background Tumor-associated macrophages (TAMs) serve as crucial modulators of the
complicated interaction between cancer cells and immune microenvironment. Sirtuin 1 …

The major obstacles for the efficacy of tumor immunotherapies are their immune-related
systemic adverse events. Therefore, tumor tropism property and pro-inflammatory ability of …

Understanding molecular mechanisms of colorectal cancer (CRC) metastasis is urgently
required for targeted therapy and prognosis of metastatic CRC. In this study, we explored …

Immunosuppressive myeloid cells hinder immunotherapeutic efficacy in tumors, but the
precise mechanisms remain undefined. Here, by performing single-cell RNA sequencing in …

SIRT1 is a mammalian NAD+-dependent histone deacetylase implicated in metabolism,
development, aging and tumorigenesis. Prior studies that examined the effect of enterocyte …

Purpose The relationship between SIRT1 and clinicopathological parameters of colorectal
cancer (CRC) is controversial. To evaluate the clinicopathological and prognostic value of …