Regulation of the macrolide resistance ABC-F translation factor MsrD
CR Fostier, F Ousalem, EC Leroy, S Ngo… - Nature …, 2023 - nature.com
A ntibiotic r esistance ABC-Fs (ARE ABC-Fs) are translation factors that provide resistance
against clinically important ribosome-targeting antibiotics which are proliferating among …
against clinically important ribosome-targeting antibiotics which are proliferating among …
ABC-F proteins mediate antibiotic resistance through ribosomal protection
Members of the ABC-F subfamily of ATP-binding cassette proteins mediate resistance to a
broad array of clinically important antibiotic classes that target the ribosome of Gram-positive …
broad array of clinically important antibiotic classes that target the ribosome of Gram-positive …
Ribosome protection by ABC‐F proteins—molecular mechanism and potential drug design
Members of the ATP‐binding cassette F (ABC‐F) proteins confer resistance to several
classes of clinically important antibiotics through ribosome protection. Recent structures of …
classes of clinically important antibiotics through ribosome protection. Recent structures of …
The ABC of ribosome-related antibiotic resistance
DN Wilson - MBio, 2016 - Am Soc Microbiol
The increase in multidrug-resistant pathogenic bacteria is limiting the utility of our current
arsenal of antimicrobial agents. Mechanistically understanding how bacteria obtain …
arsenal of antimicrobial agents. Mechanistically understanding how bacteria obtain …
Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest
Several ATPases in the ATP-binding cassette F (ABCF) family confer resistance to
macrolides, lincosamides and streptogramins (MLS) antibiotics. MLS are structurally distinct …
macrolides, lincosamides and streptogramins (MLS) antibiotics. MLS are structurally distinct …
Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens
C Crowe-McAuliffe, V Murina, KJ Turnbull… - Nature …, 2021 - nature.com
Target protection proteins confer resistance to the host organism by directly binding to the
antibiotic target. One class of such proteins are the antibiotic resistance (ARE) ATP-binding …
antibiotic target. One class of such proteins are the antibiotic resistance (ARE) ATP-binding …
Antibiotic resistance ABC-F proteins: bringing target protection into the limelight
LKR Sharkey, AJ O'Neill - ACS Infectious Diseases, 2018 - ACS Publications
Members of the ATP-binding cassette (ABC)-F protein subfamily collectively mediate
resistance to a broader range of clinically important antibiotic classes than any other group …
resistance to a broader range of clinically important antibiotic classes than any other group …
Ribosome protection by antibiotic resistance ATP-binding cassette protein
The ribosome is one of the richest targets for antibiotics. Unfortunately, antibiotic resistance
is an urgent issue in clinical practice. Several ATP-binding cassette family proteins confer …
is an urgent issue in clinical practice. Several ATP-binding cassette family proteins confer …
[HTML][HTML] ABC-F proteins in mRNA translation and antibiotic resistance
F Ousalem, S Singh, O Chesneau, JF Hunt… - Research in …, 2019 - Elsevier
The ATP binding cassette protein superfamily comprises ATPase enzymes which are, for the
most part, involved in transmembrane transport. Within this superfamily however, some …
most part, involved in transmembrane transport. Within this superfamily however, some …
Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR
N Obana, H Takada, C Crowe-McAuliffe… - Nucleic Acids …, 2023 - academic.oup.com
Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F
subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The …
subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The …