Gastric cancer is among the most prevalent and deadliest of cancers globally. To derive
mechanistic insight into the pathways governing this disease, we generated a Claudin18 …

Cancer stem cells (CSCs) have been hypothesized to represent the driving force behind
tumour progression and metastasis, making them attractive cancer targets. However …

The discovery of leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) as both
a marker of adult stem cells and a critical modulator of their activity via its role as an effector …

Cancer stem cells (CSCs) or tumor-initiating cells (TICs) are thought to be the main drivers
for disease progression and treatment resistance across various cancer types. Identifying …

The cancer stem cell (CSC) theory highlights a self-renewing subpopulation of cancer cells
that fuels tumour growth. The existence of human CSCs is mainly supported by …

The cellular origin of gastric cancer remains elusive. Leucine-rich repeat-containing G-
protein-coupled receptor 5 (Lgr5) is the first identified marker of gastric stem cells. However …

LGR5 is known to be a stem cell marker in the murine small intestine and colon, however the
localization of LGR5 in human adenoma samples has not been examined in detail and …

Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like
multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a …

Background: Gastric cancer remains the third most common cause of cancer-related death
worldwide. The development of novel therapeutic strategies for gastric cancer requires a …

The mammary gland is composed of a complex cellular hierarchy with unusual postnatal
plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells …