A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers
A Fatehullah, Y Terakado, S Sagiraju, TL Tan… - Nature Cell …, 2021 - nature.com
Gastric cancer is among the most prevalent and deadliest of cancers globally. To derive
mechanistic insight into the pathways governing this disease, we generated a Claudin18 …
mechanistic insight into the pathways governing this disease, we generated a Claudin18 …
A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
F de Sousa e Melo, AV Kurtova, JM Harnoss, N Kljavin… - Nature, 2017 - nature.com
Cancer stem cells (CSCs) have been hypothesized to represent the driving force behind
tumour progression and metastasis, making them attractive cancer targets. However …
tumour progression and metastasis, making them attractive cancer targets. However …
Recent advances in Lgr5+ stem cell research
The discovery of leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) as both
a marker of adult stem cells and a critical modulator of their activity via its role as an effector …
a marker of adult stem cells and a critical modulator of their activity via its role as an effector …
LGR5 marks targetable tumor-initiating cells in mouse liver cancer
W Cao, M Li, J Liu, S Zhang, L Noordam… - Nature …, 2020 - nature.com
Cancer stem cells (CSCs) or tumor-initiating cells (TICs) are thought to be the main drivers
for disease progression and treatment resistance across various cancer types. Identifying …
for disease progression and treatment resistance across various cancer types. Identifying …
Visualization and targeting of LGR5+ human colon cancer stem cells
M Shimokawa, Y Ohta, S Nishikori, M Matano… - Nature, 2017 - nature.com
The cancer stem cell (CSC) theory highlights a self-renewing subpopulation of cancer cells
that fuels tumour growth. The existence of human CSCs is mainly supported by …
that fuels tumour growth. The existence of human CSCs is mainly supported by …
Gastric Lgr5+ stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice
XB Li, G Yang, L Zhu, YL Tang, C Zhang, Z Ju, X Yang… - Cell research, 2016 - nature.com
The cellular origin of gastric cancer remains elusive. Leucine-rich repeat-containing G-
protein-coupled receptor 5 (Lgr5) is the first identified marker of gastric stem cells. However …
protein-coupled receptor 5 (Lgr5) is the first identified marker of gastric stem cells. However …
Characterization of LGR5 stem cells in colorectal adenomas and carcinomas
LGR5 is known to be a stem cell marker in the murine small intestine and colon, however the
localization of LGR5 in human adenoma samples has not been examined in detail and …
localization of LGR5 in human adenoma samples has not been examined in detail and …
Plasticity of Lgr5-negative cancer cells drives metastasis in colorectal cancer
Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like
multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a …
multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a …
[HTML][HTML] Single-cell landscape reveals active cell subtypes and their interaction in the tumor microenvironment of gastric cancer
Y Li, X Hu, R Lin, G Zhou, L Zhao, D Zhao, Y Zhang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: Gastric cancer remains the third most common cause of cancer-related death
worldwide. The development of novel therapeutic strategies for gastric cancer requires a …
worldwide. The development of novel therapeutic strategies for gastric cancer requires a …
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours
The mammary gland is composed of a complex cellular hierarchy with unusual postnatal
plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells …
plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells …