The no-reflow phenomenon: a basic mechanism of myocardial ischemia and reperfusion
T Reffelmann, RA Kloner - Basic research in cardiology, 2006 - Springer
Both animal models of experimental myocardial infarction and clinical studies on reperfusion
therapy for acute myocardial infarction have provided evidence of impaired tissue perfusion …
therapy for acute myocardial infarction have provided evidence of impaired tissue perfusion …
No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion
T Reffelmann, SL Hale, JS Dow, RA Kloner - Circulation, 2003 - Am Heart Assoc
Background—No-reflow after reperfusion therapy for myocardial infarction is a strong
predictor of clinical outcome. But its fate on a long-term basis and potential significance for …
predictor of clinical outcome. But its fate on a long-term basis and potential significance for …
No-reflow phenomenon in the heart and brain
The no-reflow phenomenon refers to the observation that when an organ is made ischemic
by occlusion of a large artery supplying it, restoration of patency in that artery does not …
by occlusion of a large artery supplying it, restoration of patency in that artery does not …
Evidence for decreased coronary flow reserve in viable postischemic myocardium.
J Vanhaecke, W Flameng, M Borgers, IK Jang… - Circulation …, 1990 - Am Heart Assoc
To try to unravel the complexity and heterogeneity of the" no-reflow" phenomenon and its
underlying mechanisms, we studied tissue perfusion in reperfused heart muscle by using …
underlying mechanisms, we studied tissue perfusion in reperfused heart muscle by using …
Relationship between no reflow and infarct size as influenced by the duration of ischemia and reperfusion
T Reffelmann, SL Hale, G Li… - American Journal of …, 2002 - journals.physiology.org
No reflow after acute myocardial infarction is an important predictor of infarct size and
clinical outcome. However, the exact relationship between no reflow and infarct size remains …
clinical outcome. However, the exact relationship between no reflow and infarct size remains …
No-reflow phenomenon: maintaining vascular integrity
RA Kloner - Journal of cardiovascular pharmacology and …, 2011 - journals.sagepub.com
The no-reflow phenomenon relates to the inability to reperfuse regions of the myocardium
after ischemia, despite removal of the large epicardial coronary artery occlusion. The …
after ischemia, despite removal of the large epicardial coronary artery occlusion. The …
Progressive failure of coronary flow during reperfusion of myocardial infarction: documentation of the no reflow phenomenon with positron emission tomography
RW Jeremy, JM Links, LC Becker - Journal of the American College of …, 1990 - Elsevier
During reperfusion of a myocardial infarct, development of microvascular occlusion may
result in regional hypoperfusion (“no reflow”) despite a patent infarct-related artery. This …
result in regional hypoperfusion (“no reflow”) despite a patent infarct-related artery. This …
No-reflow phenomenon and prognosis in patients with acute myocardial infarction
H Ito - Nature clinical practice Cardiovascular medicine, 2006 - nature.com
The rapid restoration of coronary flow to the jeopardized myocardium has become an
essential part of therapy after acute myocardial infarction. Despite an open infarct-related …
essential part of therapy after acute myocardial infarction. Despite an open infarct-related …
Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit
T Reffelmann, RA Kloner - American Journal of Physiology …, 2002 - journals.physiology.org
The aim was to define the degree and time course of reperfusion-related expansion of no
reflow. In five groups of anesthetized, open-chest rabbits (30-min coronary occlusion and …
reflow. In five groups of anesthetized, open-chest rabbits (30-min coronary occlusion and …
Temporal evolution and functional outcome of no reflow: sustained and spontaneously reversible patterns following successful coronary recanalisation
Objective: To identify in humans the temporal patterns of no reflow and their functional
implications. Methods: 24 patients with first acute myocardial infarction and successful …
implications. Methods: 24 patients with first acute myocardial infarction and successful …
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