A case of a young girl diagnosed with an antibody deficiency syndrome serves to highlight
the role of CD81 in B cell biology. Moreover, this case illustrates a fundamental function of …

Background CD81, a cell-surface protein of the tetraspanin superfamily, has been shown to
costimulate T cell activation in murine T cells, and is involved in development of Th2 immune …

CD81 is a widely expressed tetraspanin that associates in B cells with CD19 in the CD19-
CD21-CD81 signaling complex. CD81 is necessary for normal CD19 expression; cd81−/− B …

The tetraspanin CD81 is ubiquitously expressed and associated with CD19 on B
lymphocytes and with CD4 and CD8 on T lymphocytes. Analysis of mice with disrupted …

The tetraspanin web is composed of a network of tetraspanins and their partner proteins that
facilitate cellular interactions and fusion events by an unknown mechanism. Our aim was to …

The tetraspanin CD81 has been involved in T-dependent B cell-mediated immune
responses. However, the behavior of CD81 during immune synapse (IS) formation has not …

Mice lacking CD81 (TAPA-1), a widely expressed tetraspanin molecule, have impaired
antibody responses to protein antigens. This defect is specific to antigens that preferentially …

CD9 is a member of the tetraspanin superfamily which is characterized by four
transmembrane (TM) domains and associates with other surface molecules. This tetraspanin …

Tetraspanin protein CD9 supports sperm–egg fusion, and regulates cell adhesion, motility,
metastasis, proliferation and signaling. The large extracellular loop and transmembrane …

In this report, we provide new evidence of a crosstalk between T cell activation and
adhesion processes through a functional cytokeleton. We show that CD82 signaling induces …