Tissue stem cell exhaustion is a key hallmark of aging, and in this study, we characterised its
manifestation in the distal lung. We compared the lungs of 3-and 22-month old mice. We …

Pulmonary fibrosis comprises a range of chronic interstitial lung diseases (ILDs) that impose
a significant burden on patients and public health. Among these, idiopathic pulmonary …

The last decade has seen significant progress in understanding the organisation of
regenerative cells in the adult lung. Cell‐lineage tracing and in vitro clonogenic assays have …

Natural lung aging is marked by molecular changes that occur during development,
maturation, and late-life decline. At the cellular and whole organ level, degenerative …

Aging is the final stage of development with stereotyped changes in tissue morphology.
These age-related changes are risk factors for a multitude of chronic lung diseases …

Mechanisms that regulate progenitor cell quiescence and differentiation in slowly replacing
tissues are not fully understood. Here, we demonstrate that the tumor suppressor p53 …

Aging poses a global public health challenge, which is linked to the rise of age-related lung
diseases. The precise understanding of the molecular and genetic changes in the aging …

Dynamic changes to the developing lung endoderm during the process of lung development
result in the establishment of functionally distinct epithelial compartments that vary both in …

Aging is a critical determinant of regenerative capacity in many organ systems, but it remains
unresolved in the lung. This study examines murine lung cell dynamics during age …

Recognition of the potential of stem cell‐based therapies for alleviating intractable lung
diseases has provided the impetus for research aimed at identifying regenerative cells in the …