A single-cell transcriptome atlas profiles early organogenesis in human embryos
The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …
The single-cell transcriptional landscape of mammalian organogenesis
Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of
the three germ layers transform into an embryo that includes most of the major internal and …
the three germ layers transform into an embryo that includes most of the major internal and …
A human cell atlas of fetal gene expression
INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …
set out to generate single-cell atlases of both gene expression (this study) and chromatin …
[HTML][HTML] Single-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis
Background Organogenesis is crucial for proper organ formation during mammalian
embryonic development. However, the similarities and shared features between different …
embryonic development. However, the similarities and shared features between different …
Molecular architecture of lineage allocation and tissue organization in early mouse embryo
During post-implantation development of the mouse embryo, descendants of the inner cell
mass in the early epiblast transit from the naive to primed pluripotent state. Concurrently …
mass in the early epiblast transit from the naive to primed pluripotent state. Concurrently …
[HTML][HTML] Systematic reconstruction of cellular trajectories across mouse embryogenesis
Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …
An atlas of rabbit development as a model for single-cell comparative genomics
Traditionally, the mouse has been the favoured vertebrate model for biomedical research,
due to its experimental and genetic tractability. However, non-rodent embryological studies …
due to its experimental and genetic tractability. However, non-rodent embryological studies …
[HTML][HTML] Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues …
development. However, current approaches mostly rely on dissociating cells from tissues …
[HTML][HTML] Primate gastrulation and early organogenesis at single-cell resolution
J Zhai, J Guo, H Wan, L Qi, L Liu, Z Xiao, L Yan… - Nature, 2022 - nature.com
Our understanding of human early development is severely hampered by limited access to
embryonic tissues. Due to their close evolutionary relationship with humans, nonhuman …
embryonic tissues. Due to their close evolutionary relationship with humans, nonhuman …
Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing
Z Xue, K Huang, C Cai, L Cai, C Jiang, Y Feng, Z Liu… - Nature, 2013 - nature.com
Mammalian pre-implantation development is a complex process involving dramatic changes
in the transcriptional architecture,,,. We report here a comprehensive analysis of …
in the transcriptional architecture,,,. We report here a comprehensive analysis of …