Branched ubiquitin (Ub) chains make up a significant proportion of Ub polymers in human
cells and are formed when two or more sites on a single Ub molecule are modified with Ub …

Branched ubiquitin (Ub) chains constitute a sizable fraction of Ub polymers in human cells.
Despite their abundance, our understanding of branched Ub function in cell signaling has …

Protein ubiquitination regulates many cellular processes via attachment of structurally and
functionally distinct ubiquitin (Ub) chains. Several atypical chain types have remained poorly …

Post-translational substrate modification with ubiquitin is essential for eukaryotic cellular
signaling. Polymeric ubiquitin chains are assembled with specific architectures, which …

The linkage, length, and architecture of ubiquitin (Ub) chains are all important variables in
providing tight control over many biological paradigms. There are clear roles for branched …

The ubiquitin (Ub) code denotes the complex Ub architectures, including Ub chains of
different lengths, linkage types, and linkage combinations, which enable ubiquitination to …

Ubiquitylation is a critical post-translational modification that controls a wide variety of
processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different …

Ubiquitylation regulates a multitude of biological processes and this versatility stems from
the ability of ubiquitin (Ub) to form topologically different polymers of eight different linkage …

Ubiquitination is a versatile posttranslational modification that elicits signaling roles to
impact on various cellular processes and disease states. The versatility is a result of the …

Research on ubiquitin (Ub) signaling has focused primarily on homogeneously linked
polyUb. Although polyUb containing different linkages within the same chain exist, their …