Acute lymphoblastic leukemia with the worst prognosis is related to minimal residual
disease. Minimal residual disease not only depends on the individual peculiarities of …

Highlights•The in vitro model of bone marrow microenvironment supports a resistant acute
lymphoblastic leukemia cell subpopulation•The in vitro bone marrow microenvironment …

Highlights•The bone marrow microenvironment protects leukaemia stem cells against
therapeutic drugs.•3D ex vivo co-culture models advance translational AML research.•3D ex …

Adipocyte is a unique and versatile component of bone marrow microenvironment (BMM).
However, the dynamic evolution of Bone Marrow (BM) adipocytes from the diagnosis of B …

Targeting cancer microenvironment is currently one of the major directions in drug
development and preclinical studies in leukemia. Despite the variety of available chronic …

Acute lymphoblastic leukemia (ALL) initiates and progresses in the bone marrow, and as
such, the marrow microenvironment is a critical regulatory component in development of this …

The bone marrow microenvironment of acute myeloid leukemia (AML) consists of various
cell types and signaling factors, which serve as a niche supporting leukemia cells in their …

Ex vivo studies of human disease, such as acute myeloid leukemia, are generally limited to
the analysis of two-dimensional cultures which often misinterpret the effectiveness of …

Acute myeloid leukemias (AML) comprise a wide array of different entities, which have in
common a rapid expansion of myeloid blast cells leading to displacement of normal …

The microenvironment that surrounds a tumor, in addition to the tumor itself, plays an
important role in the onset of resistance to molecularly targeted therapies. Cancer cells and …