Telomerase promoters sequences for screening telomerase modulators
GB Morin, S Lichtsteiner, A Vasserot, R Adams… - US Patent …, 2008 - Google Patents
Telomerase reverse transcriptase is part of the telomerase complex responsible for
maintaining telomere length and increasing the replicative capacity of progenitor cells …
maintaining telomere length and increasing the replicative capacity of progenitor cells …
Compounds that increase telomerase reverse transcriptase (tert) expression and methods for using the same
WH Andrews, LA Briggs, CA Foster… - US Patent App. 12 …, 2009 - Google Patents
Compounds, and methods of using the same, are provided which increase the expression of
telomerase reverse transcriptase (TERT) in a cell. These compounds and methods find use …
telomerase reverse transcriptase (TERT) in a cell. These compounds and methods find use …
Assays for TERT promoter modulatory agents using a telomerase structural RNA component
WH Andrews, L Briggs, LK Brown, CA Foster… - US Patent …, 2007 - Google Patents
Methods and compositions for assaying an agent for TERT promoter modulatory activity are
provided. In the subject methods, an agent is contacted with a cell comprising a mutant …
provided. In the subject methods, an agent is contacted with a cell comprising a mutant …
Screening methods to identify inhibitors of telomerase activity
MD West, J Shay, W Wright, EH Blackburn - US Patent 6,368,789, 2002 - Google Patents
Method and compositions are provided for the determination of telomere length and
telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of …
telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of …
Producing telomerase activators and inhibitors by screening with purified telomerase
SL Weinrich, EM Atkinson III, SP Lichtsteiner… - US Patent …, 2006 - Google Patents
This invention provides purified telomerase and methods of purifying it. The methods involve
the use of several sequen tial steps, including the use of matrices that bind molecules …
the use of several sequen tial steps, including the use of matrices that bind molecules …
Telomerase expression repressor proteins and methods of using the same
WH Andrews, CA Foster, S Fraser… - US Patent App. 12 …, 2009 - Google Patents
Telomerase repressor proteins and nucleic acid compositions encoding the same are
provided. The Subject repressor pro teins bind to a repressor site in the TERT minimal …
provided. The Subject repressor pro teins bind to a repressor site in the TERT minimal …
Telomerase expression repressor proteins and methods of using the same
WH Andrews, CA Foster, S Fraser… - US Patent …, 2007 - Google Patents
Telomerase repressor proteins and nucleic acid compositions encoding the same are
provided. The subject repressor proteins bind to a repressor site in the TERT minimal …
provided. The subject repressor proteins bind to a repressor site in the TERT minimal …
Methods of screening for compounds that derepress or increase telomerase activity
M West, C Harley, S Weinrich, C Strahl… - US Patent App. 10 …, 2003 - Google Patents
Method and compositions are provided for the determination of telomere length and
telomerase activity, as well as the ability to increase or decrease telomerase activity in the …
telomerase activity, as well as the ability to increase or decrease telomerase activity in the …
Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression
WH Andrews, CA Foster, S Fraser, H Mohammadpour - 2002 - Google Patents
Methods and compositions are provided for modulating, and generally upregulating, the
expression of telomerase reverse transcriptase (TERT) by blocking repression of TERT …
expression of telomerase reverse transcriptase (TERT) by blocking repression of TERT …
Methods of screening for compounds that derepress or increase telomerase activity
MD West, CB Harley, SL Weinrich, CM Strahl… - US Patent …, 1999 - Google Patents
Method and compositions are provided for the determination of telomere length and
telomerase activity, as well as the ability to increase or decrease telomerase activity in the …
telomerase activity, as well as the ability to increase or decrease telomerase activity in the …