A site-selective alkylation of dehydroalanine to access protected unnatural amino acids is
described. The protocol is characterized by the wide nature of alkyl radicals employed, mild …

A robust system for the preparation of β-heteroaryl α-amino acid derivatives has been
developed using photoredox catalysis. This system operates via regiospecific activation of …

A robust method for the direct addition of unactivated tertiary amines to dehydroalanine
(Dha) derivatives has been developed. This method, which is driven by a photoredox …

Unnatural amino acids are key building blocks in therapeutically relevant peptides. Thus, the
development of novel methods to increase the structural diversity of the unnatural amino …

Unnatural amino acids (UAAs) are key building blocks with widespread application across
several scientific fields. Therefore, it is highly attractive to develop straightforward and simple …

A visible-light-enabled, photocatalyst-free conjugate addition reaction of dehydroamino
acids is disclosed. Employing 4-acyl-1, 4-dihydropyridines as both a radical reservoir and …

Unnatural chiral α-amino acids are widely used in fields of organic chemistry, biochemistry
and medicinal chemistry, and their synthesis has attracted extensive attention. Although the …

Synthesis of unnatural amino acids has long been a focus of chemistry research. Here, we
present an efficient, general method that furnishes γ-carbonyl α-amino acids via …

Conspectus Peptides are essential components of living systems and contribute to critical
biological processes, such as cell proliferation, immune defense, tumor formation, and …

An expedient synthesis of β-alkyl α-amino acids is reported via application of
decarboxylative photocatalysis. The method utilizes abundant, diverse, and inexpensive …