The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis

TM Creed, R Baldeosingh, CL Eberly… - …, 2020 - journals.biologists.com
ABSTRACT The GATA and PAX-SIX-EYA-DACH transcriptional networks (PSEDNs) are
essential for proper development across taxa. Here, we demonstrate novel PSEDN roles in …

Transgenic rescue of GATA-1–deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia

R Shimizu, K Ohneda, JD Engel, CD Trainor… - Blood, 2004 - ashpublications.org
Association of GATA-1 and its cofactor Friend of GATA-1 (FOG-1) is essential for erythroid
and megakaryocyte development. To assess functions of GATA-1–FOG-1 association during …

The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish

JD Amigo, GE Ackermann, JJ Cope… - Blood, The Journal …, 2009 - ashpublications.org
The nuclear protein FOG-1 binds transcription factor GATA-1 to facilitate erythroid and
megakaryocytic maturation. However, little is known about the function of FOG-1 during …

GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis

AN Chang, AB Cantor, Y Fujiwara… - Proceedings of the …, 2002 - National Acad Sciences
The function of GATA transcription factors in diverse developmental contexts depends in part
on physical interaction with cofactors of the Friend of GATA (FOG) family. However, previous …

Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG

AP Tsang, Y Fujiwara, DB Hom… - Genes & …, 1998 - genesdev.cshlp.org
GATA transcription factors are required for the differentiation of diverse cell types in several
species. Recent evidence suggests that their biologic activities may be modulated through …

GATA1 binding kinetics on conformation-specific binding sites elicit differential transcriptional regulation

A Hasegawa, H Kaneko, D Ishihara… - … and Cellular Biology, 2016 - Taylor & Francis
GATA1 organizes erythroid and megakaryocytic differentiation by orchestrating the
expression of multiple genes that show diversified expression profiles. Here, we …

Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression

TM Chlon, LC Doré, JD Crispino - Molecular cell, 2012 - cell.com
GATA-1 and its cofactor FOG-1 are required for the differentiation of erythrocytes and
megakaryocytes. In contrast, mast cell development requires GATA-1 and the absence of …

GATA‐1 forms distinct activating and repressive complexes in erythroid cells

P Rodriguez, E Bonte, J Krijgsveld, KE Kolodziej… - The EMBO …, 2005 - embopress.org
GATA‐1 is essential for the generation of the erythroid, megakaryocytic, eosinophilic and
mast cell lineages. It acts as an activator and repressor of different target genes, for example …

HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis

B Yan, J Yang, MY Kim, H Luo, N Cesari… - Nucleic acids …, 2021 - academic.oup.com
The activity of hematopoietic factor GATA-1 is modulated through p300/CBP-mediated
acetylation and FOG-1 mediated indirect interaction with HDAC1/2 containing NuRD …

Translational isoforms of FOG1 regulate GATA1-interacting complexes

JW Snow, SH Orkin - Journal of Biological Chemistry, 2009 - ASBMB
Erythropoietic and megakaryocytic programs are directed by the transcription factor GATA1.
Friend of GATA1 (FOG1), a protein interaction partner of GATA1, is critical for GATA1 …