Objectives To study the association of ventricular septal defect (VSD) with rare variations in
the promoter region of HAND2 gene, as well as related molecular mechanisms. Methods …

Ventricular septal defect (VSD) is the most common type of congenital heart disease.
HAND1 gene plays a crucial role in the development of the heart, but the role of the variants …

Ventricular septal defect (VSD), the most common type of congenital heart disease (CHD), is
primarily caused by cardiac dysplasia. Heart and neural crest derivatives expressed 2 …

Objective To identify the novel HAND1 mutation associated with congenital ventricular
septal defect (VSD) and to perform the functional analysis. Methods: A total of 125 patients …

BACKGROUND: The HAND1 gene encodes a basic helix–loop–helix (bHLH) transcription
factor which plays an essential role in the development of heart. Mutations in HAND1 have …

Background The basic helix-loop-helix transcription factor HAND2 plays an essential role in
cardiac morphogenesis. However, the prevalence of HAND2 mutations in congenial heart …

Congenital heart defects (CHDs), a wide variety of developmental abnormalities in the
structures of the heart and the great thoracic blood vessels, are the most common form of …

Congenital heart disease (CHD) is the most common developmental abnormality, and is the
leading noninfectious cause of mortality in neonates. Increasing evidence demonstrates that …

Background Congenital heart disease (CHD) is the most prevalent developmental defect
and principal cause of infant mortality and affects cardiac and large blood vessel structures …

Congenital heart defects (CHDs) are caused by a disruption in heart morphogenesis, which
is dependent, in part, on a network of transcription factors (TFs) that regulate myocardial …