To address the challenges associated with metabolomics analyses, such as identification of
chemical structures and elimination of experimental artifacts, we developed a platform that …

Mass spectrometry-based metabolomics is the comprehensive study of naturally occurring
small molecules collectively known as the metabolome. Given the vast structural diversity …

High-resolution mass spectrometry (MS) has advanced the study of metabolism in living
systems by allowing many metabolites to be measured in a single experiment. Although …

Metabolomics is a technique in which the small molecule component from a biological
source material is analyzed for changes resulting from some set of test conditions. Liquid …

Metabolomics is a nascent field of inquiry that emerged in the late 20 th century. It
encompasses the comprehensive profiling of metabolites across a spectrum of organisms …

Untargeted metabolomics is now widely recognized as a useful tool for exploring metabolic
changes taking place in biological systems under different conditions. By its nature, this is a …

Highlights•We review high-throughput mass spectrometry-based methods for metabolomic
analysis.•High-throughput approaches usually improve throughput at the expense of …

Quantification of metabolites is of pivotal relevance in biology, where it complements more
established omics techniques such as transcriptomics and proteomics. Here, we present a …

Metabolites are building blocks of cellular function. These species are involved in enzyme-
catalyzed chemical reactions and are essential for cellular function. Upstream biological …

Typical mass spectrometry (MS) based untargeted metabolomics protocols are tedious as
well as time-and sample-consuming. In particular, they often rely on “full-scan-only” …