Abstract Acetyl-coenzyme A (Ac-CoA) is a core metabolite with essential roles throughout
cell physiology. These functions can be classified into energetics, biosynthesis, regulation …

Acetyl-CoA represents a key node in metabolism due to its intersection with many metabolic
pathways and transformations. Emerging evidence reveals that cells monitor the levels of …

We have characterized the expression of potential acetyl-CoA-generating genes (acetyl-
CoA synthetase, pyruvate decarboxylase, acetaldehyde dehydrogenase, plastidic pyruvate …

Coenzyme A (CoA) sequestration, toxicity or redistribution (CASTOR) is predicted to occur in
many hereditary and acquired conditions in which the degradation of organic acyl esters of …

The last decade saw major advances in understanding the metabolism of Coenzyme A
(CoA) thioesters (acyl-CoAs) and related inborn errors (CoA metabolic diseases, CAMDs) …

Inherited disorders of acyl-CoA metabolism, such as defects in amino acid metabolism and
fatty acid oxidation can present with severe clinical symptoms either neonatally or later in …

In 1945, Fritz Lipmann discovered a heat-stable cofactor required for many enzyme-
catalysed acetylation reactions. He later determined the structure for this acetylation …

Acetyl-coenzyme A (acetyl-CoA) is a central metabolic intermediate. The abundance of
acetyl-CoA in distinct subcellular compartments reflects the general energetic state of the …

▪ Abstract Long-chain fatty acids are involved in all aspects of cellular structure and function.
For controlling amounts of fatty acids, cells are endowed with two acetyl-coenzyme A …

Acetyl-CoA carboxylases (ACC1 and ACC2) catalyze the carboxylation of acetyl-CoA to form
malonyl-CoA, an intermediate metabolite that plays a pivotal role in the regulation of fatty …