Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with
several underlying pathophysiological mechanisms, some of which are still uncertain. The …

Diabetic peripheral neuropathy (DPN) often leads to neurotrophic ulcerations in the cornea
and skin; however, the underlying cellular mechanisms of this complication are poorly …

Diabetic keratopathy is characterized by impaired innervation of the cornea that leads to
decreased sensitivity, with resultant difficulties with epithelial wound healing. These …

Diabetes mellitus is a chronic disease that results from inadequate insulin production or
ineffective insulin utilization. It is one of the most common systemic diseases worldwide with …

The incidence of diabetes mellitus (DM) and its complications have increased considerably
worldwide. Diabetic keratopathy is the major complication of the cornea characterized by …

In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by
trigeminal nerve damage, which leads to loss of corneal sensitivity, corneal epithelium …

Corneal nerves are instrumental to maintain cornea integrity through regulation of key
physiological functions such as tear secretion, blink reflex, and neuropeptide turnover …

Corneal nerves are key components of the physiological system that controls ocular surface
homeostasis. The cornea is primarily innervated by the ophthalmic branch of the trigeminal …

Diabetes mellitus is a major disease worldwide, and the prevalence of diabetes has risen
significantly in the past several decades. Although one of the major complications of diabetic …