The molecular mechanisms by which kidney stones grow are largely unknown. Organic
molecules from the urine combine with mineral crystals to form stones, but analysis of the …

Stone formation is induced by an increased level of urine crystallization promoters and
reduced levels of its inhibitors. Crystallization inhibitors include citrate, magnesium, zinc …

Even though renal stones/calculi occur in∼ 10% of individuals, they are an enormous
economic burden to the entire US health system. While the relative metabolic composition of …

Urolithiasis is a multifactorial disease involving environmental and gentic factors. Calcium-
containing stones, which are> 90% of all stones, detected most frequently; however …

Despite its critical nature, the role of matrix in calcium oxalate stone formation is poorly
understood. The wide diversity of proteins comprising matrix has contributed to the …

Throughout history, kidney stones have posed a serious threat to human health. The urinary
hydrological system is equipped with numerous growth-inhibiting biomolecules that usually …

Introduction: Kidney stone matrix proteins may help explain cellular mechanisms of stone
genesis. However, most existing proteomic studies have focused on calcium oxalate stones …

Background The increasing number of patients suffering from urolithiasis represents one of
the major challenges which nephrologists face worldwide today. For enhancing therapeutic …

Calcium oxalate kidney stones contain low amounts of proteins, some of which have been
implicated in progression or prevention of kidney stone formation. To gain insights into the …

Kidney stones are aggregates of microcrystals, most commonly containing calcium oxalate
monohydrate (COM) as the primary constituent. The formation of these aggregates in the …