Antimalarials are used to treat dermatomyositis (DM) and cutaneous lupus erythematosus
(CLE). Although hydroxychloroquine (HCQ) is frequently used, addition of quinacrine (QC) …

Although antimalarials are the primary treatment for cutaneous lupus erythematosus, not all
patients are equally responsive. We investigated whether different inflammatory cell …

Quinacrine (QC) is an anti‐inflammatory drug that has been used for the treatment of malaria
and rheumatoid diseases. The mechanism (s) underlying the anti‐inflammatory activity of …

Objective To demonstrate response to antimalarial agents in patients with cutaneous lupus
erythematosus (CLE) using activity scores from the Cutaneous Lupus Erythematosus …

Background Hydroxychloroquine sulfate and other antimalarial drugs have been used
successfully as adjunctive therapy for patients with cutaneous lesions of dermatomyositis …

Objective The efficacy of both chloroquine and hydroxychloroquine in rheumatoid arthritis
(RA) has been proved in controlled clinical trials. Despite similar chemical characteristics, it …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can be
exacerbated by exposure to ultraviolet radiation (UVR). The number and phenotype of …

Background Although existing evidence demonstrates the efficacy of antimalarials for
rheumatic skin disease, the safety of these medications, and particularly quinacrine, remains …

An alternate approach would be to further test the hypothesis that the pharmacokinetic and
pharmacodynamic parameters of HCQ in smokers compared to nonsmokers are …

Although chloroquine, hydroxychloroquine and quinacrine were originally developed for the
treatment of malaria, these medications have been used to treat skin disease for over 50 …