Background Ingestion of alcoholic beverages is a known trigger of migraine attacks.
However, whether and how ethanol exerts its pro-migraine action remains poorly known …

Ethanol stimulating transient receptor potential vanilloid 1 (TRPV1) on primary sensory
neurons promotes neurogenic inflammation, including calcitonin gene-related peptide …

The pathophysiological mechanism underlying migraine-associated peripheral
hypersensitivity remains unclear. Acid-sensing ion channels (ASICs) and transient receptor …

Glyceryl trinitrate is administered as a provocative test for migraine pain. Glyceryl trinitrate
causes prolonged mechanical allodynia in rodents, which temporally correlates with …

Preclinical data point to the contribution of transient receptor potential ankyrin 1 (TRPA1)
channels to the complex mechanisms underlying migraine pain. TRPA1 channels are …

Migraine is triggered by poor air quality and odors through unknown mechanisms. Activation
of the trigeminovascular pathway by environmental irritants may occur via activation of …

The TRPA1 receptor is a member of the transient receptor potential (TRP) family of ion
channels expressed in nociceptive neurons. TRPA1 receptors are targeted by pungent …

Despite intense investigation, the mechanisms of the different forms of trigeminal
neuropathic pain remain substantially unidentified. The transient receptor potential ankyrin 1 …

Six transient receptor potential (TRP) ion channels expressed in the sensory afferents play
an important role as body thermosensors and also as peripheral pain detectors. It is known …

Background The capsaicin and heat responsive ion channel TRPV1 is expressed on
trigeminal nociceptive neurons and has been implicated in the pathophysiology of migraine …