High-resistance rates in carbapenem-resistant GNB in many countries will inevitably
complicate treatment of serious infections in vulnerable patient groups and should …

The prevalence of carbapenem-resistant gram-negative bacterial pathogens (CRGNs) has
increased dramatically during the last 10 years, but the optimal treatment for CRGN …

Infections caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-
negative bacteria (GNB), including carbapenem-resistant (CR) Enterobacterales (CRE; …

Background Carbapenem-resistant gram-negative bacteria (CRGNB) continue to present a
global healthcare crisis. We aimed to identify emerging trends of CRGNB over nearly 2 …

Carbapenem-resistant Enterobacteriaceae (CRE) are a serious public health threat.
Infections due to these organisms are associated with significant morbidity and mortality …

Highlights•Carbapenem-resistant Gram-negative pathogens are a priority for R&D,
according to WHO.•Increasing need for new therapies against Klebsiella, Pseudomonas and …

Carbapenem resistance in gram-negative bacteria has caused a global epidemic that
continues to grow. Although carbapenemase-producing Enterobacteriaceae have received …

Background Rates of colonization and infection with carbapenem-resistant Gram-negative
pathogens are on the rise, particularly in southeastern European countries, and this is …

Global trade and mobility of people has increased rapidly over the last 20 years. This has
had profound consequences for the evolution and the movement of antibiotic resistance …

AFTER MORE THAN 7DECADES OF ANTIBIOTIC USE, A RE-current pattern of
antimicrobial resistance spread is evident among certain bacterial pathogens. In this pattern …