Genetic renal phosphate leak is one of the rare disorders in recurrent stone formers with
absorptive hypercalciuria. Diagnosis and appropriate management may change the life of …

Calcium kidney stones are common worldwide. Most are idiopathic and composed of
calcium oxalate. Calcium phosphate is present in around 80% and may initiate stone …

Background Hypercalciuria is the most frequent metabolic disorder encountered in kidney
stone formers (SF). Reduced renal phosphate reabsorption (ie renal phosphate leak) was …

Background Hypophosphatemia (HYP) is common among calcium stone formers (SFs) and
in rare cases is associated with mutations in sodium-phosphate cotransporters or in Na+/H+ …

Apart from increased fluid intake, patients with kidney stone disease (KSD) due to renal
phosphate wasting require specific metaphylaxis. NaPi2a, NaPi2c, and NHERF1 regulate …

Frequency of renal phosphate leak among patients with calcium nephrolithiasis.
Background Nephrolithiasis is a frequent disorder affecting 10 to 15% of the population in …

Purpose Recent studies have suggested that renal phosphate leakage and the associated
phosphaturia are significant underlying causes of calcium urolithiasis. The aims of this study …

A decrease in renal phosphate reabsorption with mild hypophosphatemia (phosphate leak)
is found in some hypercalciuric stone-formers. The NPT2a gene encodes a sodium …

Loss-of-function mutations of SLC34A3 represent an established cause of a distinct renal
phosphate wasting disorder termed hereditary hypophosphatemic rickets with hypercalciuria …

Purpose: Recent studies have suggested a defect in phosphate balance as a significant
underlying cause of calcium urolithiasis. In this study we assessed the influence of …