This study examined the short-and long-term neuroprotective and analgesic activity of
honokiol (a naturally occurring lignan isolated from Magnolia) on developing brains in …

Objective Premature and ill neonates undergo painful but medically necessary procedures
while hospitalized. Although opiate drugs are administered as analgesics, problems …

Honokiol is a poly-phenolic compound that exerts neuroprotective properties through a
variety of mechanisms. It has therapeutic potential in anxiety, pain, cerebrovascular injury …

The antinociceptive actions of honokiol and magnolol, two major bioactive constituents of
the bark of Magnolia officinalis, were evaluated using tail-flick, hot-plate and formalin tests in …

Compounds isolated from Magnolia officinalis such as magnolol, honokiol and obovatol
exhibit several pharmacological effects on CNS including depressant, anxiolytic and …

Honokiol has previously been shown to be an effective anxiolytic-like agent in mice when
administered for 7 days at 0.2 mg/kg/day prior to evaluation in an elevated plus-maze, while …

Inhibitory neurotransmitters such as gamma-aminobutyric acid (GABA) and glycine are
known to be abundant in the substantia gelatinosa (SG) of the trigeminal subnucleus …

Honokiol is a neolignan biphenol found in aerial parts of the Magnolia plant species. The
Magnolia plant species traditionally belong to China and have been used for centuries to …

Oxytocin (OT), known for its neurohormonal effects around birth, has recently been
suggested for being a critical determinant in neurodevelopmental disorders. This …

The present study investigates the possible anti-nociceptive effect of intraperitoneal (ip)
honokiol: a phenolic compound originally isolated from Magnolia officinalis, in acute and …