MSP-RON pathway: potential regulator of inflammation and innate immunity

L Huang, X Fang, D Shi, S Yao, W Wu, Q Fang… - Frontiers in …, 2020 - frontiersin.org
Macrophage-stimulating protein (MSP), a soluble protein mainly synthesized by the liver, is
the only known ligand for recepteur d'origine nantais (RON), which is a member of the MET …

MSP–RON signalling in cancer: pathogenesis and therapeutic potential

HP Yao, YQ Zhou, R Zhang, MH Wang - Nature reviews Cancer, 2013 - nature.com
Since the discovery of MSP (macrophage-stimulating protein; also known as MST1 and
hepatocyte growth factor-like (HGFL)) as the ligand for the receptor tyrosine kinase RON …

Proteolytic activation of pro-macrophage-stimulating protein by hepsin

R Ganesan, GA Kolumam, SJ Lin, MH Xie… - Molecular Cancer …, 2011 - AACR
Macrophage-stimulating protein (MSP) is a plasminogen-related growth factor and ligand for
the receptor tyrosine kinase RON. The MSP/RON system promotes wound healing and …

Macrophage‐stimulating protein and RON receptor tyrosine kinase: potential regulators of macrophage inflammatory activities

MH Wang, YQ Zhou, YQ Chen - Scandinavian journal of …, 2002 - Wiley Online Library
Macrophage‐stimulating protein (MSP) is a serum protein belonging to the plasminogen‐
related growth factor family. The specific receptor for MSP is the RON (recepteur d'origine …

Inhibition of MSP-RON signaling pathway in cancer cells by a novel soluble form of RON comprising the entire sema sequence

Q Ma, K Zhang, HP Yao, YQ Zhou… - International …, 2010 - spandidos-publications.com
The RON receptor tyrosine kinase and its ligand macrophage stimulating protein (MSP) play
a role in epithelial tumorigenesis. We report here a novel RON variant that antagonizes the …

The macrophage stimulating protein/Ron pathway as a potential therapeutic target to impede multiple mechanisms involved in breast cancer progression

KL Kretschmann, H Eyob, SS Buys… - Current drug …, 2010 - ingentaconnect.com
Macrophage Stimulating Protein (MSP) is the only known ligand for the receptor tyrosine
kinase Ron. The MSP/Ron pathway is involved in several important biological processes …

A network map of macrophage-stimulating protein (MSP) signaling

D Sanjeev, S Dagamajalu, V Shaji, M George… - Journal of Cell …, 2023 - Springer
Abstract Macrophage-stimulating protein (MSP), a serum-derived growth factor belonging to
the plasminogen-related kringle domain family, is mainly produced by the liver and released …

Cross-talk between RON receptor tyrosine kinase and other transmembrane receptors

A Danilkovitch-Miagkova, EJ Leonard - Histology and histopathology, 2001 - revistas.um.es
RON is a transmembrane receptor tyrosine kinase that mediates biological activities of
Macrophage Stimulating Protein (MSP). MSP is a multifunctional factor regulating cell …

Oncogenic signaling pathways activated by RON receptor tyrosine kinase

A Danilkovitch-Miagkova - Current cancer drug targets, 2003 - ingentaconnect.com
RON (Receptuer d'Origine Nantaise) is a member of the MET receptor tyrosine kinase
family. RON is expressed in various cell types including macrophages, epithelial and …

Differential expression of RON in small and non–small cell lung cancers

R Kanteti, S Krishnaswamy, D Catenacci… - Genes …, 2012 - Wiley Online Library
RON is a MET related receptor tyrosine kinase (RTK) and its natural ligand is macrophage
stimulating protein (MSP). RON plays a very important role in the regulation of inflammation …