Impact of obesity on oral contraceptive pharmacokinetics and hypothalamic–pituitary–ovarian activity

AB Edelman, NE Carlson, G Cherala, MY Munar… - Contraception, 2009 - Elsevier
BACKGROUND: This study was conducted to determine whether increased body mass
index (BMI) affects oral contraceptive (OC) pharmacokinetics and suppression of …

Correcting oral contraceptive pharmacokinetic alterations due to obesity: a randomized controlled trial

AB Edelman, G Cherala, MY Munar, M McInnis… - Contraception, 2014 - Elsevier
Objective To determine if increasing the hormone dose or eliminating the hormone-free
interval improves key pharmacokinetic (PK) alterations caused by obesity during oral …

Pharmacokinetics of a combined oral contraceptive in obese and normal-weight women

CL Westhoff, AH Torgal, ER Mayeda, MC Pike… - Contraception, 2010 - Elsevier
BACKGROUND: This study was conducted to compare oral contraceptive (OC)
pharmacokinetics (PK) in normal-weight [body mass index (BMI) 19.0–24.9] and obese (BMI …

[HTML][HTML] Hormonal contraception and obesity

KB Simmons, AB Edelman - Fertility and sterility, 2016 - Elsevier
The rising rate of overweight and obesity is a public health crisis in the United States and
increasingly around the globe. Rates of contraceptive use are similar among women of all …

Prolonged monitoring of ethinyl estradiol and levonorgestrel levels confirms an altered pharmacokinetic profile in obese oral contraceptives users

AB Edelman, G Cherala, MY Munar, B DuBois… - Contraception, 2013 - Elsevier
BACKGROUND: Pharmacokinetic (PK) parameters based on short sampling times (48 h or
less) may contain inaccuracies due to their dependency on extrapolated values. This study …

Ovarian suppression in normal-weight and obese women during oral contraceptive use: a randomized controlled trial

CL Westhoff, AH Torgal, ER Mayeda… - Obstetrics & …, 2010 - journals.lww.com
OBJECTIVE: To assess ovarian suppression during oral contraceptive pill (OCP) use among
normal-weight and obese women using two OCP doses. METHODS: This was a …

Obesity and oral contraceptive pill failure

J Trussell, EB Schwarz, K Guthrie - Contraception, 2009 - contraceptionjournal.org
Oral contraceptive pills (OCPs) are the most popular form of reversible contraception in the
United States [1]. Most commonly used OCPs contain a combination of estrogen and …

Effect of obesity on the effectiveness of hormonal contraceptives: an individual participant data meta-analysis

M Yamazaki, K Dwyer, M Sobhan, D Davis, MJ Kim… - Contraception, 2015 - Elsevier
Objective The objective of this investigation was to assess the potential effect of obesity on
the effectiveness of hormonal contraceptives (HCs). Study Design A meta-analysis was …

Obesity and hormonal contraceptive efficacy

JA Robinson, AE Burke - Women's health, 2013 - journals.sagepub.com
Obesity is a major public health concern affecting an increasing proportion of reproductive-
aged women. Avoiding unintended pregnancy is of major importance, given the increased …

Association between efficacy and body weight or body mass index for two low-dose oral contraceptives

RT Burkman, AC Fisher, GJ Wan, CE Barnowski… - Contraception, 2009 - Elsevier
BACKGROUND: This analysis investigated the association of oral contraceptive efficacy with
body weight and body mass index (BMI) for hypothesis-generating purposes. STUDY …