Ischemic heart failure (IHF) is a leading cause of morbidity and mortality worldwide, for
which heart transplantation remains the only definitive treatment. IHF manifests from …

Myocardial Infarction (MI) is the most common cardiovascular disease. An average-sized MI
causes the loss of up to 1 billion cardiomyocytes and the adult heart lacks the capacity to …

Cardiac remodeling after myocardial infarction (MI) is characterized by deleterious changes
in cardiac geometry and constitutes the prevailing pathomechanism in the development of …

Despite decades of research, regeneration of the infarcted human heart remains an unmet
ambition. A significant obstacle facing experimental regenerative therapies is the hostile …

Purpose Despite modern reperfusion and pharmacologic therapies, myocardial infarction
(MI) remains a leading cause of morbidity and mortality worldwide. Therefore, the …

Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

The regenerative capacity of adult human tissues and organs is limited, but recent
developments have seen the advent of promising new technologies for regenerative …

Extensive necrosis of ischemic cardiomyocytes in the infarcted myocardium activates the
innate immune response triggering an intense inflammatory reaction. Release of danger …

Heart regenerative medicine has been gradually evolving from a view of the heart as a
nonregenerative organ with terminally differentiated cardiac muscle cells. Understanding the …

Significant progress has been made in methods for cardiac repair and regeneration within
the past few decades; however, the diseased microenvironment of the infarct remains a …