The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+ 4'cell markers
Two types of stem cells are currently defined in small intestinal crypts: cycling crypt base
columnar (CBC) cells and quiescent '+ 4'cells. Here, we combine transcriptomics with …
columnar (CBC) cells and quiescent '+ 4'cells. Here, we combine transcriptomics with …
[HTML][HTML] Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
Intestinal stem cells, characterized by high Lgr5 expression, reside between Paneth cells at
the small intestinal crypt base and divide every day. We have carried out fate mapping of …
the small intestinal crypt base and divide every day. We have carried out fate mapping of …
Small intestinal stem cell markers
RK Montgomery, DT Breault - Journal of anatomy, 2008 - Wiley Online Library
Stem cells hold great promise for regenerative medicine but remain elusive in many tissues,
including the small intestine, where it is well accepted that the epithelium is maintained by …
including the small intestine, where it is well accepted that the epithelium is maintained by …
Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67‐RFP allele
Cycling Lgr5+ stem cells fuel the rapid turnover of the adult intestinal epithelium. The
existence of quiescent Lgr5+ cells has been reported, while an alternative quiescent stem …
existence of quiescent Lgr5+ cells has been reported, while an alternative quiescent stem …
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells
LG Van der Flier, A Haegebarth, DE Stange… - …, 2009 - gastrojournal.org
The epithelium of the small intestine and colon is the most rapidly self-renewing tissue in
mammals. Proliferative cells are confined to crypts, and differentiated cell types …
mammals. Proliferative cells are confined to crypts, and differentiated cell types …
[PDF][PDF] Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy
The recent development of targeted murine reporter alleles as proxies for intestinal stem cell
activity has led to significant advances in our understanding of somatic stem cell hierarchies …
activity has led to significant advances in our understanding of somatic stem cell hierarchies …
Identification of a cKit+ colonic crypt base secretory cell that supports Lgr5+ stem cells in mice
BACKGROUND & AIMS: Paneth cells contribute to the small intestinal niche of Lgr5+ stem
cells. Although the colon also contains Lgr5+ stem cells, it does not contain Paneth cells. We …
cells. Although the colon also contains Lgr5+ stem cells, it does not contain Paneth cells. We …
In situ validation of an intestinal stem cell signature in colorectal cancer
JL Ziskin, D Dunlap, M Yaylaoglu, IK Fodor, WF Forrest… - Gut, 2013 - gut.bmj.com
Objective Wnt/Tcf, Lgr5, Ascl2 and/or Bmi1 signalling is believed to define the mouse
intestinal stem cell niche (s) from which adenomas arise. The aim of this study was to …
intestinal stem cell niche (s) from which adenomas arise. The aim of this study was to …
Stem cells marked by the R-spondin receptor LGR5
Since the discovery of LGR5 as a marker of intestinal stem cells, the field has developed
explosively and led to many new avenues of research. The inner workings of the intestinal …
explosively and led to many new avenues of research. The inner workings of the intestinal …
Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells
TH Kim, S Escudero… - Proceedings of the …, 2012 - National Acad Sciences
Lifelong self-renewal of the adult intestinal epithelium requires the activity of stem cells
located in mucosal crypts. Lgr5 and Bmi1 are two molecular markers of crypt-cell …
located in mucosal crypts. Lgr5 and Bmi1 are two molecular markers of crypt-cell …