[HTML][HTML] Sex dimorphism in the tumor microenvironment–from bench to bedside and back
F He, AR Furones, N Landegren, J Fuxe… - Seminars in cancer …, 2022 - Elsevier
Cancer represents a significant cause of death and suffering in both the developed and
developing countries. Key underlying issues in the mortality of cancer are delayed diagnosis …
developing countries. Key underlying issues in the mortality of cancer are delayed diagnosis …
Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications
T Xiao, J Lee, TD Gauntner, M Velegraki… - Nature Reviews …, 2024 - nature.com
Sex differences are present across multiple non-reproductive organ cancers, with male
individuals generally experiencing higher incidence of cancer with poorer outcomes …
individuals generally experiencing higher incidence of cancer with poorer outcomes …
[HTML][HTML] Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang
J Ma, Y Yao, Y Tian, K Chen, B Liu - Biology of sex Differences, 2022 - Springer
A wide sex disparity has been demonstrated in cancer incidence, tumor aggressiveness,
prognosis, and treatment response of different types of cancer. The sex specificity of cancer …
prognosis, and treatment response of different types of cancer. The sex specificity of cancer …
Pan‐cancer analysis reveals sex‐specific signatures in the tumor microenvironment
J Han, Y Yang, X Li, J Wu, Y Sheng, J Qiu… - Molecular …, 2022 - Wiley Online Library
The processes of cancer initiation, progression, and response to therapy are affected by the
sex of cancer patients. Immunotherapy responses largely depend on the tumor …
sex of cancer patients. Immunotherapy responses largely depend on the tumor …
[HTML][HTML] Sex and gender influences on cancer immunotherapy response
A Irelli, MM Sirufo, C D'Ugo, L Ginaldi, M De Martinis - Biomedicines, 2020 - mdpi.com
The global burden of cancer is growing and a wide disparity in the incidence, malignancy
and mortality of different types of cancer between each sex has been demonstrated. The sex …
and mortality of different types of cancer between each sex has been demonstrated. The sex …
Sex-based differences in the tumor microenvironment
V Wuidar, L Gillot, I Dias Da Silva, A Lebeau… - Tumor …, 2021 - Springer
Cancers are heterogeneous multifactorial diseases consisting of a major public health issue
worldwide. Sex disparities are evidenced in cancer incidence, mortality, expression of …
worldwide. Sex disparities are evidenced in cancer incidence, mortality, expression of …
[HTML][HTML] Sex and cancer immunotherapy: Current understanding and challenges
Recent evidence highlights patients' sex relevance in antitumor immune response through a
complex interaction—among hormones, genes, behaviors, and the microbiome—that affects …
complex interaction—among hormones, genes, behaviors, and the microbiome—that affects …
Connecting the mechanisms of tumor sex differences with cancer therapy
H Li, W Jiang, S Liu, M Yang, S Chen, Y Pan… - Molecular and Cellular …, 2024 - Springer
Sex differences in cancer incidence and survival are constant and pronounced globally,
across all races and all age groups of cancer types. In 2016, after the National Institutes of …
across all races and all age groups of cancer types. In 2016, after the National Institutes of …
[HTML][HTML] Sex-biased adaptive immune regulation in cancer development and therapy
The cancer research field is finally starting to unravel the mystery behind why males have a
higher incidence and mortality rate than females for nearly all cancer types of the non …
higher incidence and mortality rate than females for nearly all cancer types of the non …
Sex differences in cancer and immunotherapy outcomes: the role of androgen receptor
Across the wide range of clinical conditions, there exists a sex imbalance where biological
females are more prone to autoimmune diseases and males to some cancers. These …
females are more prone to autoimmune diseases and males to some cancers. These …