Ectopic calcification is a driving force for a variety of diseases, including kidney stones and
atherosclerosis, but initiating factors remain largely unknown. Given its importance in …

Purpose: The limitations imposed by human clinical studies and mammalian models of
nephrolithiasis have hampered the development of effective medical treatments and …

Kidney stone disease involves the aggregation of stone-forming salts consequent to solute
supersaturation in urine. The development of novel therapeutic agents for this predominantly …

Background Zinc is an essential metal involved in many physiological processes. Previous
work has identified a set of zinc transporters involved in Drosophila dietary zinc absorption …

Renal stone disease is a frequent condition, causing a huge burden on health care systems
globally. Calcium-based calculi account for around 75% of renal stone disease and the …

Nephrolithiasis is a major public health problem with a complex and varied etiology. Most
stones are composed of calcium oxalate (CaOx), with dietary excess a risk factor. Because …

We previously established a mouse kidney stone formation model and showed that mice
have a higher tolerance to stone formation than rats. Furthermore, we showed that the …

Even though the prevalence of nephrolithiasis is increasing, our understanding of the
pathophysiology has not kept pace and new therapeutic approaches have not emerged. The …

Better understanding of molecular mechanisms for kidney stone formation is required to
improve management of kidney stone disease with better therapeutic outcome. Recent …

Kidney stone disease (KSD) is a complex disorder with high heritability and prevalence. We
performed a large genome-wide association study (GWAS) meta-analysis for KSD to date …