Downregulation of PTPRT elevates the expression of survivin and promotes the proliferation, migration, and invasion of lung adenocarcinoma

C Chen, H Liu, Y Li, Q Xu, J Liu - BMC cancer, 2024 - Springer
Background Receptor-type tyrosine-protein phosphatase T (PTPRT) is a transmembrane
protein that is involved in cell adhesion. We previously found that PTPRT was …

Overexpression of PTPRN promotes metastasis of lung adenocarcinoma and suppresses NK cell cytotoxicity

X Song, X Jiao, H Yan, L Yu, L Jiang… - Frontiers in Cell and …, 2021 - frontiersin.org
Background Lung adenocarcinoma (LUAD) is the most common diagnostic histologic
subtype of non-small cell lung cancer, but the role of receptor-type tyrosine-protein …

Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types

C Chen, H Liu, Q Xu, X Zhang, F Mu… - BioMed Research …, 2022 - Wiley Online Library
Metastasis is one of the characteristics of advanced cancer and the primary cause of cancer‐
related deaths from cancer, but the mechanism underlying metastasis is unclear, and there …

Increased PTPRA expression leads to poor prognosis through c-Src activation and G1 phase progression in squamous cell lung cancer

Z Gu, X Fang, C Li, C Chen… - International …, 2017 - spandidos-publications.com
PTPRA is reported to be involved in cancer development and progression through activating
the Src family kinase (SFK) signaling pathways, however, the roles of PTPRA in the …

Protein tyrosine phosphatase PTPRB regulates Src phosphorylation and tumour progression in NSCLC

Y Qi, Y Dai, S Gui - Clinical and Experimental Pharmacology …, 2016 - Wiley Online Library
Protein tyrosine‐phosphatases (PTP s) play important roles in various biological processes.
Deregulation in PTP function has been implicated in carcinogenesis and tumour …

[HTML][HTML] PTPRO predicts patient prognosis and correlates with immune infiltrates in human clear cell renal cell carcinoma

J Gan, H Zhang - Translational Cancer Research, 2020 - ncbi.nlm.nih.gov
Background The tumor-suppressive role of protein tyrosine phosphatase receptor type O
(PTPRO) has been described in a variety of human cancers; however, the clinical …

[HTML][HTML] The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells

S D'Agostino, D Lanzillotta, M Varano, C Botta… - Oncotarget, 2018 - ncbi.nlm.nih.gov
PTPRJ, a receptor protein tyrosine phosphatase strongly downregulated in human cancer,
displays tumor suppressor activity by negatively modulating several proteins involved in …

PTPRF as a novel tumor suppressor through deactivation of ERK1/2 signaling in gastric adenocarcinoma

X Tian, C Yang, L Yang, Q Sun, N Liu - OncoTargets and therapy, 2018 - Taylor & Francis
Background Protein tyrosine phosphatase, receptor type F (PTPRF) is an important
phosphatase playing roles in regulating cell growth, differentiation and oncogenic …

Aberrant expression of proPTPRN2 in cancer cells confers resistance to apoptosis

AV Sorokin, BC Nair, Y Wei, KE Aziz, V Evdokimova… - Cancer research, 2015 - AACR
The protein tyrosine phosphatase receptor PTPRN2 is expressed predominantly in
endocrine and neuronal cells, where it functions in exocytosis. We found that its immature …

PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer

H Liu, Y Wu, S Zhu, W Liang, Z Wang, Y Wang, T Lv… - Cancer letters, 2015 - Elsevier
Previous studies have demonstrated that protein tyrosine phosphatase 1B (PTP1B) can
promote tumor progression in breast cancer, colon cancer and prostate cancer. Additionally …