The earliest description of what is now known as the acute respiratory distress syndrome
(ARDS) was a highly lethal double pneumonia. Ashbaugh and colleagues (Ashbaugh DG …

The adverse effects of mechanical ventilation in acute respiratory distress syndrome (ARDS)
arise from two main causes: unphysiological increases of transpulmonary pressure and …

Optimizing gas exchange, avoiding lung injury, and preserving respiratory muscle strength
and endurance are vital therapeutic objectives for managing acute lung injury. Accordingly …

Mechanical ventilation has been used to support acutely ill patients for several decades. But
clinicians are aware that, despite the life-saving potential of this assistance, it has several …

This review addresses the physiological background and the current status of evidence
regarding ventilator‐induced lung injury and lung protective strategies. Lung protective …

Mechanical ventilation applies physical stresses to the tissues of the lung and thus may give
rise to ventilator-induced lung injury (VILI), particular in patients with acute respiratory …

The passage of 30 years since the initial description of the acute respiratory distress
syndrome (ARDS) has brought substantial insight into its epidemiology and …

Unequivocal evidence from both experimental and clinical research has shown that
mechanical ventilation can damage the lungs and initiate an inflammatory response …

Acute respiratory distress syndrome (ARDS) remains a serious clinical problem with the
main treatment being supportive in the form of mechanical ventilation. However, mechanical …

Interest in modified techniques for ventilating patients with acute lung injury (ALI) has been
driven by an evolving knowledge of the respiratory mechanics of this condition and the …