Aminoquinolines are an important class of antimalarial drugs because they are effective
against the liver stages of Plasmodium infections and thus are administered for radical cure …

Primaquine is an antimalarial drug of the 8-aminoquinoline class. It has prophylactic activity,
relatively weak schizontocidal activity and radical curative activity in Plasmodium vivax and …

Because 8-aminoquinolines affect critical survival stages of Plasmodium parasites,
treatment and control of malaria could be markedly improved by more widespread use of …

Tafenoquine is an 8-aminoquiniline related to primaquine with pre-clinical activity against a
range of malaria species. We treated two acute cases of vivax malaria with tafenoquine (800 …

Primaquine was firstly synthesized in 1946 in the USA, and is the most representative
member of the anti-malarial 8-aminoquinolines. Six decades have passed and primaquine …

The technical genesis and practice of 8-aminoquinoline therapy of latent malaria offer
singular scientific, clinical, and public health insights. The 8-aminoquinolines brought …

Malaria is a significant public health problem in developing and third world countries.
Plasmodium falciparum and Plasmodium vivax parasites are responsible for the majority of …

In an attempt to separate the antimalarial activity of tafenoquine (3) from its hemolytic side
effects in glucose-6-phosphate dehydrogenase (G6PD) deficiency patients, a series of 5-aryl …

Introduction: A century-long history in 8-aminoquinolines, the only anti-malaria drug class
preventing malaria relapse, has resulted in the approval of tafenoquine by the US Food and …

Malaria remains an important cause of global morbidity and mortality. As antimalarial drug
resistance escalates, new safe and effective medications are necessary to prevent and treat …