Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma

Y Yu, C Liang, Q Tang, Y Shi, L Shen - Gene, 2024 - Elsevier
Background m6A regulators have important roles in a variety of autoimmune diseases, but
their potential function in scleroderma, a refractory connective tissue disease, remains …

Construction and validation of m6A-related diagnostic model for psoriasis

J Liu, Y Wang, Y Sheng, L Cai, Y Wang - PeerJ, 2024 - peerj.com
Background Psoriasis is a chronic immune-mediated inflammatory disease. N6-
methyladenosine (m6A) is involved in numerous biological processes in both normal and …

Alteration of the m6A Methylation Landscape in a Mouse Model of Scleroderma

L Shen, Y Yu, M Jiang, J Zhao - Epigenomics, 2021 - Taylor & Francis
Aim: To explore the N6-methyladenosine (m6A) methylation of mRNAs and its roles in a
mouse model of scleroderma. Materials & methods: To evaluate whether the mouse model …

[HTML][HTML] Significance of m6A in subtype identification, immunological evolution, and therapeutic sensitivity of RA

C Ma, J Wu, H Lei, H Huang, Y Li - Immunobiology, 2024 - Elsevier
Abstract N6-methyladenosine (m6A) is one kind of important epigenetic modification pattern
which is extensively involved in immune regulation. The development and progression of …

Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages

Y Lu, H Zhang, H Pan, Z Zhang, H Zeng, H Xie… - Journal of Translational …, 2023 - Springer
Background Disruption of N6 methyl adenosine (m6A) modulation hampers gene
expression and cellular functions, leading to various illnesses. However, the role of m6A …

Significance of m6A regulatory factor in gene expression and immune function of osteoarthritis

X Xie, Y Zhang, J Yu, F Jiang, C Wu - Frontiers in Physiology, 2022 - frontiersin.org
One of the most prevalent posttranscriptional modifications of eukaryotic mRNA is the RNA
N6-methyladenosine (m6A) regulator, which plays a significant role in various illnesses. The …

Characterization of immune microenvironment infiltration and m6A regulator-mediated RNA methylation modification patterns in osteoarthritis

Y Ouyang, Y Tu, S Chen, H Min, Z Wen… - Frontiers in …, 2022 - frontiersin.org
Background Few studies have been reported the potential role of N6-methyladenosine
(m6A) modification in osteoarthritis (OA). We investigated the patterns of m6A modification in …

Diagnostic value and immune infiltration characterization of YTHDF2 as a critical m6A regulator in osteoarthritic synovitis

A Bian, C Wang, H Zhang, Y Yan, L Zhang… - Journal of Orthopaedic …, 2023 - Springer
Abstract Background N6-methyladenosine (m6A) is a universal RNA modification pattern
regulated by multiple m6A regulators. In osteoarthritis (OA), m6A regulators influence …

Exploration of potential integrated models of N6-methyladenosine immunity in systemic lupus erythematosus by bioinformatic analyses

X Zhao, L Ge, J Wang, Z Song, B Ni, X He… - Frontiers in …, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease of
unknown etiology. The epigenetic regulation of N6-methyladenosine (m6A) modification in …

Identification of m6A-related biomarkers in systemic lupus erythematosus: a bioinformation-based analysis

Y Tian, K Tao, S Li, X Chen, R Wang… - Journal of …, 2024 - Taylor & Francis
Background Systemic Lupus Erythematosus (SLE), a prototypical autoimmune disorder,
presents a challenge due to the absence of reliable biomarkers for discerning organ-specific …