Blood lipid levels mediating the effects of sex hormone-binding globulin on coronary heart disease: Mendelian randomization and mediation analysis
J Yang, J Zhou, H Liu, J Hao, S Hu, P Zhang, H Wu… - Scientific Reports, 2024 - nature.com
Observational studies indicate that serum sex hormone-binding globulin (SHBG) levels are
inversely correlated with blood lipid levels and coronary heart disease (CHD) risk. Given that …
inversely correlated with blood lipid levels and coronary heart disease (CHD) risk. Given that …
Sex hormone-binding globulin and risk of coronary heart disease in men and women
Background The role of sex hormone-binding globulin (SHBG) levels in clinical risk
stratification and intervention for coronary heart disease (CHD) remains uncertain. We …
stratification and intervention for coronary heart disease (CHD) remains uncertain. We …
Genetically predicted sex hormone binding globulin and ischemic heart disease in men and women: a univariable and multivariable Mendelian randomization study
JV Zhao, CM Schooling - Scientific Reports, 2021 - nature.com
Men are more vulnerable to ischemic heart disease (IHD) than women, possibly due to
testosterone. Correspondingly, sex hormone binding globulin (SHBG) which lowers …
testosterone. Correspondingly, sex hormone binding globulin (SHBG) which lowers …
[HTML][HTML] Causal effect of sex hormone-binding globulin and testosterone on coronary heart disease: a multivariable and network Mendelian randomization analysis
Y Li, S Si, L Hou, T Yuan, X Chen, C Liu, W Li… - International journal of …, 2021 - Elsevier
Background Although observational studies have shown an association between sex
hormone-binding globulin (SHBG), testosterone (T) and cardiovascular diseases (CVD) …
hormone-binding globulin (SHBG), testosterone (T) and cardiovascular diseases (CVD) …
Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates
Q Wang, AJ Kangas, P Soininen… - International journal …, 2015 - academic.oup.com
Background: The causal role of circulating sex hormone-binding globulin (SHBG) for type 2
diabetes is controversial. Information on the relations between SHBG and new biomarkers of …
diabetes is controversial. Information on the relations between SHBG and new biomarkers of …
Aging, cardiovascular risk, and SHBG levels in men and women from the general population
Aims Prior studies have reported inconsistent results for the association between sex
hormone-binding globulin (SHBG) and cardiovascular disease among men and women …
hormone-binding globulin (SHBG) and cardiovascular disease among men and women …
Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population
B Daka, T Rosen, PA Jansson, CA Larsson… - BMC Cardiovascular …, 2013 - Springer
Background The aim of this study was to investigate the association of sex hormone-binding
globulin (SHBG) and hypertension in a Swedish population. Methods The study is based on …
globulin (SHBG) and hypertension in a Swedish population. Methods The study is based on …
Sex Hormone-binding globulin and its association to cardiovascular risk factors in an Italian adult population cohort
B Buttari, R Riganò, L Palmieri, C Lo Noce… - Reports, 2022 - mdpi.com
Abnormal sex hormone-binding globulin (SHBG) and sex hormone concentrations are the
cause or the consequence of cardiometabolic diseases, however, the clinical correlates of …
cause or the consequence of cardiometabolic diseases, however, the clinical correlates of …
Classic and novel sex hormone binding globulin effects on the cardiovascular system in men
C Basualto-Alarcón, P Llanos… - International Journal …, 2021 - Wiley Online Library
In men, 70% of circulating testosterone binds with high affinity to plasma sex hormone
binding globulin (SHBG), which determines its bioavailability in their target cells. In recent …
binding globulin (SHBG), which determines its bioavailability in their target cells. In recent …
[PDF][PDF] Impact of sex hormone-binding globulin on the human phenome
R Arathimos, LAC Millard, JA Bell… - Human molecular …, 2020 - academic.oup.com
Background: Sex hormone-binding globulin (SHBG) is a circulating glycoprotein and a
regulator of sex hormone levels, which has been shown to influence various traits and …
regulator of sex hormone levels, which has been shown to influence various traits and …
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