Immune parameters affecting the efficacy of chemotherapeutic regimens

L Zitvogel, O Kepp, G Kroemer - Nature reviews Clinical oncology, 2011 - nature.com
The outcome of chemotherapy can be influenced by the host immune system at multiple
levels. Chemotherapy can kill cancer cells by causing them to elicit an immune response or …

Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy

S Gnjatic, V Bronte, LR Brunet, MO Butler… - … for immunotherapy of …, 2017 - Springer
As cancer strikes, individuals vary not only in terms of factors that contribute to its occurrence
and development, but as importantly, in their capacity to respond to treatment. While exciting …

The immune system in cancer pathogenesis: potential therapeutic approaches

PH Pandya, ME Murray, KE Pollok… - Journal of …, 2016 - Wiley Online Library
Interplay among immune activation and cancer pathogenesis provides the framework for a
novel subspecialty known as immunooncology. In the rapidly evolving field of …

[HTML][HTML] High-dimensional immune-profiling in cancer: implications for immunotherapy

S Chuah, V Chew - Journal for immunotherapy of cancer, 2020 - ncbi.nlm.nih.gov
Immunotherapy is a rapidly growing field for cancer treatment. In contrast to conventional
cancer therapies, immunotherapeutic strategies focus on reactivating the immune system to …

Cancer immunology—analysis of host and tumor factors for personalized medicine

S Ogino, J Galon, CS Fuchs, G Dranoff - Nature reviews Clinical …, 2011 - nature.com
Immune cells in the tumor microenvironment have an important role in regulating tumor
progression. Therefore, stimulating immune reactions to tumors can be an attractive …

Immunologic biomarkers as correlates of clinical response to cancer immunotherapy

ML Disis - Cancer immunology, immunotherapy, 2011 - Springer
Over the last few years, several newly developed immune-based cancer therapies have
been shown to induce clinical responses in significant numbers of patients. As a result, there …

Emerging opportunities and challenges in cancer immunotherapy

TL Whiteside, S Demaria, ME Rodriguez-Ruiz… - Clinical Cancer …, 2016 - AACR
Immunotherapy strategies against cancer are emerging as powerful weapons for treatment
of this disease. The success of checkpoint inhibitors against metastatic melanoma and …

Immune responses to cancer: are they potential biomarkers of prognosis?

TL Whiteside - Frontiers in oncology, 2013 - frontiersin.org
Recent technical improvements in evaluations of immune cells in situ and immune
monitoring of patients with cancer have provided a wealth of new data confirming that …

Novel technologies and emerging biomarkers for personalized cancer immunotherapy

J Yuan, PS Hegde, R Clynes, PG Foukas… - … for immunotherapy of …, 2016 - Springer
The culmination of over a century's work to understand the role of the immune system in
tumor control has led to the recent advances in cancer immunotherapies that have resulted …

Immune-mediated mechanisms influencing the efficacy of anticancer therapies

SB Coffelt, KE de Visser - Trends in immunology, 2015 - cell.com
Conventional anticancer therapies, such as chemotherapy, radiotherapy, and targeted
therapy, are designed to kill cancer cells. However, the efficacy of anticancer therapies is not …