Microglia and perivascular macrophages act as antigen presenting cells to promote CD8 T cell infiltration of the brain
EN Goddery, CE Fain, CG Lipovsky… - Frontiers in …, 2021 - frontiersin.org
CD8 T cell infiltration of the central nervous system (CNS) is necessary for host protection
but contributes to neuropathology. Antigen presenting cells (APCs) situated at CNS borders …
but contributes to neuropathology. Antigen presenting cells (APCs) situated at CNS borders …
The CNS immune landscape from the viewpoint of a T cell
Neuro-immune interactions are not only vital for the control of neurotropic pathogens, but
also appear to influence brain development and homeostasis. During immune surveillance …
also appear to influence brain development and homeostasis. During immune surveillance …
Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation
The central nervous system (CNS) is under close surveillance by immune cells, which
mediate tissue homeostasis, protection, and repair. Conversely, in neuroinflammation …
mediate tissue homeostasis, protection, and repair. Conversely, in neuroinflammation …
Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response
A Wlodarczyk, M Løbner, O Cédile, T Owens - Journal of …, 2014 - Springer
Background Tissue-resident antigen-presenting cells (APC) exert a major influence on the
local immune environment. Microglia are resident myeloid cells in the central nervous …
local immune environment. Microglia are resident myeloid cells in the central nervous …
An antigen-specific pathway for CD8 T cells across the blood-brain barrier
I Galea, M Bernardes-Silva, PA Forse… - The Journal of …, 2007 - rupress.org
CD8 T cells are nature's foremost defense in encephalitis and brain tumors. Antigen-specific
CD8 T cells need to enter the brain to exert their beneficial effects. On the other hand, traffic …
CD8 T cells need to enter the brain to exert their beneficial effects. On the other hand, traffic …
Resident and infiltrating central nervous system APCs regulate the emergence and resolution of experimental autoimmune encephalomyelitis
AE Juedes, NH Ruddle - The Journal of Immunology, 2001 - journals.aai.org
During experimental autoimmune encephalomyelitis (EAE), autoreactive Th1 T cells invade
the CNS. Before performing their effector functions in the target organ, T cells must …
the CNS. Before performing their effector functions in the target organ, T cells must …
The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis
S Prasad, S Hu, WS Sheng, P Chauhan… - Journal of …, 2017 - Springer
Background Previous work from our laboratory has demonstrated that during acute viral
brain infection, glial cells modulate antiviral T cell effector responses through the PD-1: PD …
brain infection, glial cells modulate antiviral T cell effector responses through the PD-1: PD …
Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown
S Aydin, J Pareja, VM Schallenberg, A Klopstein… - Nature …, 2023 - nature.com
Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous
system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8+ T cells …
system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8+ T cells …
A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation
VH Perry - Journal of neuroimmunology, 1998 - Elsevier
There are numerous observations reporting that phagocytes expressing major
histocompatibility complex (MHC) Class II molecules are associated with the central nervous …
histocompatibility complex (MHC) Class II molecules are associated with the central nervous …
Brain dendritic cells and macrophages/microglia in central nervous system inflammation
HG Fischer, G Reichmann - The Journal of Immunology, 2001 - journals.aai.org
Microglia subpopulations were studied in mouse experimental autoimmune
encephalomyelitis and toxoplasmic encephalitis. CNS inflammation was associated with the …
encephalomyelitis and toxoplasmic encephalitis. CNS inflammation was associated with the …